Detailed information of TA system TA076905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 681594..682198
• Replicon: chromosome
• Accession: NZ_CP021659
• Organism: Candidatus Fukatsuia symbiotica strain 5D

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CCS41_RS03250
• Protein ID: WP_119797199.1
• Coordinates: 681887..682198 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCS41_RS03245
• Protein ID: WP_119797198.1
• Coordinates: 681594..681884 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS41_RS03210	677341..677829	-	489	WP_119797196.1	antiterminator	-
CCS41_RS03215	677826..678188	-	363	WP_119797012.1	RusA family crossover junction endodeoxyribonuclease	-
CCS41_RS03220	678225..679097	-	873	WP_119797197.1	ATP-binding protein	-
CCS41_RS03225	679102..679980	-	879	WP_119797011.1	helix-turn-helix domain-containing protein	-
CCS41_RS03230	680182..680586	-	405	Protein_632	transposase	-
CCS41_RS03235	680639..681007	-	369	WP_072549715.1	IS630 transposase-related protein	-
CCS41_RS03240	681013..681567	+	555	Protein_634	terminase	-
CCS41_RS03245	681594..681884	-	291	WP_119797198.1	helix-turn-helix domain-containing protein	Antitoxin
CCS41_RS03250	681887..682198	-	312	WP_119797199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCS41_RS03255	682245..682871	+	627	WP_205411480.1	hypothetical protein	-
CCS41_RS03260	682873..683277	-	405	Protein_638	transposase	-
CCS41_RS03265	683330..683698	-	369	WP_072549715.1	IS630 transposase-related protein	-
CCS41_RS03270	683700..684074	+	375	WP_119797200.1	hypothetical protein	-
CCS41_RS03275	684092..685114	-	1023	WP_119797201.1	IS630 family transposase	-
CCS41_RS03280	685153..685449	+	297	WP_119797202.1	transposase	-
CCS41_RS16015	685374..685589	+	216	WP_205411481.1	hypothetical protein	-
CCS41_RS03285	685625..686041	-	417	WP_205411482.1	hypothetical protein	-
CCS41_RS03290	686059..686301	-	243	WP_205411483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	665693..686271	20578

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-88)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12105.04 Da
• Isoelectric Point: 9.6564

>T76905 WP_119797199.1 NZ_CP021659:c682198-681887 [Candidatus Fukatsuia symbiotica]
MIFIETDIFTEDCKALLRDDEYRELQQYLTDNPEVGDVITHTGGLRKVRWAAKGKGKRSGVRIIYYHKVAVSHIRLLLIY
KKGIKDDLSTDEKKVLRILNERW

Nucleotide

• Length: 312 bp

>T76905 NZ_CP021659:c682198-681887 [Candidatus Fukatsuia symbiotica]
ATGATTTTTATTGAAACCGATATATTCACAGAAGATTGCAAAGCATTACTTCGCGACGATGAGTATCGGGAATTACAACA
ATATCTTACTGATAATCCAGAAGTCGGCGATGTCATTACACATACTGGCGGATTACGTAAAGTACGCTGGGCGGCAAAAG
GTAAAGGTAAGCGCAGTGGTGTTAGAATTATTTACTATCATAAGGTCGCTGTGTCTCACATCAGGTTGTTGCTGATTTAC
AAAAAAGGGATAAAAGACGACTTAAGTACGGATGAAAAAAAAGTATTACGTATTCTGAATGAAAGGTGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10549.15 Da
• Isoelectric Point: 11.1078

>AT76905 WP_119797198.1 NZ_CP021659:c681884-681594 [Candidatus Fukatsuia symbiotica]
MDKKLFSRLTESMKQMNNIIEGNASPSRETVCSNVKVKTIRQATGLTQSGFARLLAVNVGTLRNWEQGRREPTGPAKALL
RAIDNDPTHVLKALSA

Nucleotide

• Length: 291 bp

>AT76905 NZ_CP021659:c681884-681594 [Candidatus Fukatsuia symbiotica]
ATGGATAAAAAACTCTTTTCTCGATTAACCGAAAGCATGAAGCAGATGAACAACATTATCGAGGGTAATGCCTCTCCTTC
TCGTGAAACTGTTTGCAGTAATGTCAAGGTAAAAACTATCAGACAGGCAACCGGTTTGACTCAAAGCGGGTTTGCTCGGT
TACTGGCTGTTAATGTGGGCACGTTACGTAACTGGGAACAGGGACGACGTGAACCCACAGGCCCAGCTAAAGCTTTATTA
CGAGCCATTGATAACGATCCGACGCATGTACTAAAAGCACTGTCAGCCTGA