Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3380748..3381354 Replicon chromosome
Accession NZ_CP021648
Organism Acidovorax sp. T1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CCX87_RS15745 Protein ID WP_087747647.1
Coordinates 3381028..3381354 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCX87_RS15740 Protein ID WP_087747646.1
Coordinates 3380748..3381038 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCX87_RS15715 3376875..3377507 - 633 WP_087747642.1 hypothetical protein -
CCX87_RS15720 3377631..3378824 - 1194 WP_087748410.1 trypsin-like serine protease -
CCX87_RS15725 3378988..3379857 - 870 WP_087747643.1 hypothetical protein -
CCX87_RS15735 3380133..3380468 - 336 WP_087747645.1 hypothetical protein -
CCX87_RS15740 3380748..3381038 - 291 WP_087747646.1 transcriptional regulator Antitoxin
CCX87_RS15745 3381028..3381354 - 327 WP_087747647.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCX87_RS15750 3381387..3382013 - 627 WP_143218316.1 hypothetical protein -
CCX87_RS15755 3382035..3382547 - 513 WP_198314725.1 hypothetical protein -
CCX87_RS21145 3382549..3382686 - 138 WP_198314726.1 hypothetical protein -
CCX87_RS15760 3382688..3382996 - 309 WP_087747649.1 BrnA antitoxin family protein -
CCX87_RS15765 3382956..3383228 - 273 WP_087747650.1 BrnT family toxin -
CCX87_RS15770 3383434..3383724 - 291 WP_087747651.1 helix-turn-helix domain-containing protein -
CCX87_RS15775 3383727..3384038 - 312 WP_087747652.1 type II toxin-antitoxin system RelE/ParE family toxin -
CCX87_RS15780 3384310..3385419 - 1110 WP_087747653.1 transposase -
CCX87_RS15785 3385470..3385721 - 252 Protein_3123 transposase -
CCX87_RS15790 3385749..3386096 - 348 WP_087747654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-86)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12172.18 Da        Isoelectric Point: 9.1362

>T76886 WP_087747647.1 NZ_CP021648:c3381354-3381028 [Acidovorax sp. T1]
MVFVELPIFVRCAQDMFSDDDLRELQVTLLKNPAAGDLILGGRGLRKLRVPLPGRGKRGGARVIYYHWVSHDQCLLVFAY
AKNVAADLTKDQLRRLADVIDVEVNHGR

Download         Length: 327 bp

>T76886 NZ_CP021648:c3381354-3381028 [Acidovorax sp. T1]
ATGGTCTTTGTTGAGTTACCCATCTTCGTGCGCTGCGCACAAGATATGTTTTCGGACGATGACCTGCGTGAGCTACAAGT
TACCTTGCTGAAAAATCCGGCCGCTGGGGATTTGATTCTCGGTGGCCGAGGTCTTCGCAAGTTGCGTGTTCCGTTGCCTG
GGCGAGGAAAACGAGGCGGCGCCAGAGTGATCTACTACCACTGGGTCAGCCATGATCAGTGCTTGTTGGTCTTTGCCTAC
GCCAAGAATGTGGCCGCTGACTTGACCAAGGACCAGCTAAGGCGCCTGGCCGATGTGATTGATGTGGAGGTGAACCATGG
ACGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10870.57 Da        Isoelectric Point: 10.6485

>AT76886 WP_087747646.1 NZ_CP021648:c3381038-3380748 [Acidovorax sp. T1]
MDDKQFDDLLASVRDMGRHMRGEVVVGAKVREFPEPDVKAIRERTGLSQTRFAYLIGVRPKTLQNWEQHRVRPAGPARAL
LKIVEANPNALTLLHA

Download         Length: 291 bp

>AT76886 NZ_CP021648:c3381038-3380748 [Acidovorax sp. T1]
ATGGACGATAAGCAATTTGACGACCTGCTGGCGAGCGTTCGCGACATGGGTCGCCACATGCGTGGCGAAGTGGTTGTGGG
TGCGAAGGTACGCGAATTTCCAGAGCCCGACGTCAAGGCCATCCGGGAACGTACTGGCCTGAGCCAGACCCGTTTCGCTT
ACCTGATCGGCGTCAGGCCCAAGACCCTCCAGAACTGGGAGCAGCACCGGGTTCGTCCGGCCGGTCCCGCCCGTGCACTG
CTGAAGATTGTCGAAGCCAACCCTAACGCACTGACGCTTCTTCACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References