Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3241563..3242065 Replicon chromosome
Accession NZ_CP021532
Organism Escherichia coli strain AR_0149

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag AM396_RS16620 Protein ID WP_000767829.1
Coordinates 3241563..3241817 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag AM396_RS16625 Protein ID WP_001259255.1
Coordinates 3241814..3242065 (-) Length 84 a.a.

Genomic Context

AM396_RS16630AM396_RS16640AM396_RS16645AM396_RS16650AM396_RS16655AM396_RS16595AM396_RS16600AM396_RS16605AM396_RS25635AM396_RS16610AM396_RS16615AM396_RS16620AM396_RS16625
Location: 3242348..3242398 (51 bp)
Type: Others
Protein ID: WP_001364200.1
Location: 3242544..3243443 (900 bp)
Type: Others
Protein ID: WP_000131792.1
Location: 3243449..3244753 (1305 bp)
Type: Others
Protein ID: WP_001367667.1
Location: 3244750..3245820 (1071 bp)
Type: Others
Protein ID: WP_000108941.1
Location: 3245820..3246887 (1068 bp)
Type: Others
Protein ID: WP_000080141.1
Location: 3236578..3236805 (228 bp)
Type: Others
Protein ID: WP_000985273.1
Location: 3236819..3237877 (1059 bp)
Type: Others
Protein ID: WP_000492333.1
Location: 3238056..3239414 (1359 bp)
Type: Others
Protein ID: WP_000019197.1
Location: 3239404..3239466 (63 bp)
Type: Others
Protein ID: WP_010723108.1
Location: 3239681..3240610 (930 bp)
Type: Others
Protein ID: WP_000803351.1
Location: 3240656..3241480 (825 bp)
Type: Others
Protein ID: WP_000754737.1
Location: 3241563..3241817 (255 bp)
Type: Toxin
Protein ID: WP_000767829.1
Location: 3241814..3242065 (252 bp)
Type: Antitoxin
Protein ID: WP_001259255.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AM396_RS165953236578..3236805-228WP_000985273.1sulfurtransferase TusA family protein-
AM396_RS166003236819..3237877-1059WP_000492333.1transport protein YeeE-
AM396_RS166053238056..3239414-1359WP_000019197.1putrescine/proton symporter PlaP-
AM396_RS256353239404..3239466-63WP_010723108.1membrane protein YoeI-
AM396_RS166103239681..3240610-930WP_000803351.1LysR family transcriptional regulator-
AM396_RS166153240656..3241480-825WP_000754737.1SDR family oxidoreductase-
AM396_RS166203241563..3241817-255WP_000767829.1type II toxin-antitoxin system mRNA interferase toxin YoeBToxin
AM396_RS166253241814..3242065-252WP_001259255.1YoeB-YefM toxin-antitoxin system antitoxin YefMAntitoxin
AM396_RS166303242348..3242398+51WP_001364200.1his operon leader peptide-
AM396_RS166403242544..3243443+900WP_000131792.1ATP phosphoribosyltransferase-
AM396_RS166453243449..3244753+1305WP_001367667.1histidinol dehydrogenase-
AM396_RS166503244750..3245820+1071WP_000108941.1histidinol-phosphate transaminase-
AM396_RS166553245820..3246887+1068WP_000080141.1bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T76751 WP_000767829.1 NZ_CP021532:c3241817-3241563 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T76751 NZ_CP021532:c3241817-3241563 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT76751 WP_001259255.1 NZ_CP021532:c3242065-3241814 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT76751 NZ_CP021532:c3242065-3241814 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6NY6
PDB2A6S
PDB6OXA
PDB2A6R
PDB4V8X
PDB6OTR
PDB6OXI
PDB2A6Q

Antitoxin

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Source
ID
Structure
PDB2A6Q
AlphaFold DBA0A7U9LNR0

References