Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1249912..1250561 Replicon chromosome
Accession NZ_CP021389
Organism Bifidobacterium breve strain NRBB57

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag NRBB57_RS05540 Protein ID WP_080988535.1
Coordinates 1249912..1250256 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NRBB57_RS05545 Protein ID WP_106620823.1
Coordinates 1250253..1250561 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB57_RS05505 1245447..1246517 + 1071 WP_106620819.1 hypothetical protein -
NRBB57_RS05510 1246639..1246767 - 129 Protein_1035 site-specific DNA-methyltransferase -
NRBB57_RS11565 1246764..1246916 - 153 WP_157826587.1 hypothetical protein -
NRBB57_RS05515 1247190..1247774 - 585 Protein_1037 hypothetical protein -
NRBB57_RS11570 1247932..1248105 + 174 WP_157826588.1 hypothetical protein -
NRBB57_RS05520 1248118..1248666 + 549 WP_106620820.1 hypothetical protein -
NRBB57_RS05525 1248668..1249018 - 351 WP_106620821.1 hypothetical protein -
NRBB57_RS05530 1249015..1249554 - 540 WP_106620822.1 hypothetical protein -
NRBB57_RS05535 1249551..1249841 - 291 WP_052791120.1 hypothetical protein -
NRBB57_RS05540 1249912..1250256 + 345 WP_080988535.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NRBB57_RS05545 1250253..1250561 + 309 WP_106620823.1 XRE family transcriptional regulator Antitoxin
NRBB57_RS05550 1250576..1250863 - 288 WP_106620824.1 hypothetical protein -
NRBB57_RS05555 1250860..1251327 - 468 WP_106620825.1 hypothetical protein -
NRBB57_RS05560 1251327..1251524 - 198 WP_052791124.1 hypothetical protein -
NRBB57_RS05565 1251524..1252165 - 642 WP_106620826.1 hypothetical protein -
NRBB57_RS05570 1252162..1252755 - 594 WP_101026238.1 hypothetical protein -
NRBB57_RS05575 1252752..1253228 - 477 WP_106621181.1 hypothetical protein -
NRBB57_RS05580 1253484..1253687 - 204 WP_013582586.1 hypothetical protein -
NRBB57_RS05585 1253738..1253986 - 249 WP_052791130.1 hypothetical protein -
NRBB57_RS05590 1253995..1254264 - 270 WP_106620827.1 hypothetical protein -
NRBB57_RS05595 1254277..1254615 - 339 WP_106620828.1 hypothetical protein -
NRBB57_RS05600 1254612..1255238 - 627 WP_106620829.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(6-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-84)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13267.32 Da        Isoelectric Point: 10.2444

>T76581 WP_080988535.1 NZ_CP021389:1249912-1250256 [Bifidobacterium breve]
MEPIKDWLDGLDKQTAYQVYAALDLLRERGPNLKRPLVGKIEGSIIGSMKELRPGSAGRSEVRILFVFDPERKAVLLVGG
DKQNKWNKWYKTAIREAERRYIRWLEEQHGKDTK

Download         Length: 345 bp

>T76581 NZ_CP021389:1249912-1250256 [Bifidobacterium breve]
ATGGAACCCATCAAGGACTGGCTTGACGGACTTGACAAACAGACCGCCTACCAGGTCTACGCGGCCCTAGACCTCCTTCG
GGAACGCGGACCGAACCTCAAACGCCCCCTGGTGGGGAAAATCGAGGGCTCCATCATCGGCTCCATGAAGGAACTGAGAC
CCGGTTCGGCAGGCCGAAGCGAAGTCCGAATCCTGTTCGTCTTCGACCCGGAACGCAAAGCGGTCCTATTGGTCGGCGGA
GACAAACAGAACAAATGGAACAAATGGTATAAGACAGCCATCCGCGAAGCCGAACGACGATACATCCGATGGCTGGAAGA
ACAACATGGGAAGGACACGAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11925.59 Da        Isoelectric Point: 5.9342

>AT76581 WP_106620823.1 NZ_CP021389:1250253-1250561 [Bifidobacterium breve]
MSYTLEDFKADHDLDQKTIDERKEQLLEEMRLYELKEARKRQDVTQKQLAERMGVSQKRVSSLESGDVDKTEIRTLRRYL
DAIGGKLQVNVVMPDGRTLQLV

Download         Length: 309 bp

>AT76581 NZ_CP021389:1250253-1250561 [Bifidobacterium breve]
ATGAGCTACACGTTGGAGGACTTCAAGGCCGATCACGACCTTGACCAGAAGACCATCGACGAGCGCAAGGAACAGCTTCT
TGAGGAGATGCGCCTGTACGAGCTGAAAGAGGCCCGCAAGCGGCAGGACGTGACCCAGAAGCAGCTCGCCGAACGCATGG
GCGTCAGCCAGAAGCGGGTCAGCAGCCTCGAATCCGGCGACGTCGACAAAACCGAAATCCGCACTCTGCGCAGATACCTC
GACGCGATTGGAGGCAAGCTGCAGGTCAATGTGGTCATGCCTGACGGCCGCACCCTGCAACTGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References