Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2814654..2815315 Replicon chromosome
Accession NZ_CP021377
Organism Oceanisphaera profunda strain SM1222

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CBP31_RS12460 Protein ID WP_087037766.1
Coordinates 2814968..2815315 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CBP31_RS12455 Protein ID WP_087037764.1
Coordinates 2814654..2814956 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBP31_RS12440 2811523..2811888 + 366 WP_087037757.1 hypothetical protein -
CBP31_RS12445 2812160..2813551 + 1392 WP_087037759.1 serine hydrolase -
CBP31_RS12450 2813732..2814508 + 777 WP_087037761.1 glucose 1-dehydrogenase -
CBP31_RS12455 2814654..2814956 - 303 WP_087037764.1 XRE family transcriptional regulator Antitoxin
CBP31_RS12460 2814968..2815315 - 348 WP_087037766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CBP31_RS12465 2816055..2816393 - 339 WP_087037768.1 thioredoxin family protein -
CBP31_RS12470 2816945..2817994 + 1050 WP_087037770.1 DUF2235 domain-containing protein -
CBP31_RS12475 2818176..2819258 + 1083 WP_087038746.1 hypothetical protein -
CBP31_RS12480 2819508..2820227 + 720 WP_161492523.1 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-79)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13061.04 Da        Isoelectric Point: 6.4688

>T76554 WP_087037766.1 NZ_CP021377:c2815315-2814968 [Oceanisphaera profunda]
MWEVETTDLFDEWFDAQDEPTQEKVLAGMLALQKGGPSTGRPLVDTVNASAYLNMKELRIQHMGGPLRAFFAFDPARTAI
ILCADNKVGDEKRFYKKMIPIADKEYARHLATLKR

Download         Length: 348 bp

>T76554 NZ_CP021377:c2815315-2814968 [Oceanisphaera profunda]
ATGTGGGAAGTTGAAACCACAGACCTATTTGACGAGTGGTTTGATGCGCAAGATGAACCAACTCAGGAAAAAGTCTTGGC
TGGTATGCTTGCATTACAAAAGGGTGGCCCCAGTACCGGTCGCCCCTTGGTAGATACGGTTAATGCGTCTGCATACCTCA
ATATGAAGGAACTGCGAATTCAGCATATGGGAGGTCCGCTAAGAGCATTTTTCGCTTTTGATCCAGCCCGCACCGCTATA
ATTCTGTGTGCCGATAACAAGGTGGGAGATGAAAAACGCTTCTACAAAAAAATGATACCAATAGCAGATAAAGAATACGC
CAGACACCTGGCGACATTAAAACGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11012.88 Da        Isoelectric Point: 10.3388

>AT76554 WP_087037764.1 NZ_CP021377:c2814956-2814654 [Oceanisphaera profunda]
MARKLSDMLASRSTKSRDRIEKTADKMLIEVKIQAVREELAMSQAELAAAMGISQPSVAALEQRGADMKISSMKRYVEAA
GGKMRIDIELPTGKHIGFNF

Download         Length: 303 bp

>AT76554 NZ_CP021377:c2814956-2814654 [Oceanisphaera profunda]
ATGGCAAGAAAACTGAGCGATATGCTGGCCTCACGATCCACCAAAAGCCGAGATCGTATCGAAAAAACAGCTGACAAAAT
GCTGATTGAAGTGAAAATTCAGGCTGTTCGAGAGGAATTGGCTATGTCACAAGCTGAGCTCGCCGCCGCTATGGGGATCA
GCCAGCCTTCTGTTGCGGCTCTTGAACAACGTGGGGCCGATATGAAGATCTCCAGCATGAAGCGCTATGTTGAAGCTGCC
GGTGGCAAGATGCGAATAGATATTGAGCTACCTACCGGTAAACATATCGGCTTCAATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References