Detailed information of TA system TA076543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2544724..2545420
• Replicon: chromosome
• Accession: NZ_CP021361
• Organism: Acidovorax carolinensis strain NA3

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CBP34_RS11865
• Protein ID: WP_094098128.1
• Coordinates: 2545124..2545420 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: CBP34_RS11860
• Protein ID: WP_086912710.1
• Coordinates: 2544724..2545122 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBP34_RS11840	2540812..2542455	-	1644	WP_208616328.1	restriction endonuclease subunit S	-
CBP34_RS11845	2542491..2542949	-	459	WP_208616401.1	hypothetical protein	-
CBP34_RS11850	2542933..2543961	-	1029	WP_094097336.1	IS30 family transposase	-
CBP34_RS11855	2544051..2544638	-	588	WP_086912709.1	nucleotidyltransferase domain-containing protein	-
CBP34_RS11860	2544724..2545122	-	399	WP_086912710.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CBP34_RS11865	2545124..2545420	-	297	WP_094098128.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CBP34_RS11870	2545439..2546905	-	1467	WP_094098129.1	type I restriction-modification system subunit M	-
CBP34_RS11875	2547005..2548183	-	1179	WP_094098130.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2542933..2543961	1028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10938.65 Da
• Isoelectric Point: 7.2755

>T76543 WP_094098128.1 NZ_CP021361:c2545420-2545124 [Acidovorax carolinensis]
MEKSTPHCKLTVVKALLQDGKFRVTRSARTGAEAMGIDFQGMLTVISALQASDFYKSMTTHADHTIWQDVYRTSSPLGDV
YLKLTVVDDLLIVSFKEL

Nucleotide

• Length: 297 bp

>T76543 NZ_CP021361:c2545420-2545124 [Acidovorax carolinensis]
ATGGAAAAGAGCACACCGCATTGCAAGCTGACCGTCGTCAAGGCCCTGCTGCAAGATGGCAAGTTTCGCGTGACGCGTTC
AGCGCGCACCGGGGCAGAGGCCATGGGCATCGACTTCCAAGGCATGCTGACCGTGATTTCGGCGCTGCAGGCGTCAGACT
TTTATAAAAGCATGACCACCCATGCCGACCACACCATCTGGCAAGACGTGTACCGCACCAGCTCGCCGCTGGGGGATGTC
TATCTCAAGTTGACCGTGGTCGATGACCTGCTGATCGTGTCTTTCAAGGAGCTATGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14602.74 Da
• Isoelectric Point: 5.2741

>AT76543 WP_086912710.1 NZ_CP021361:c2545122-2544724 [Acidovorax carolinensis]
MKCPVCGAAELIHDTRDETYTYKGESTVIPAVTGDFCPACDESLLDPAETERVMREMRAFTQQVNAAFVAPGYITEVRKK
LALDQREAAEIFGGGVNAFSRYETGKTRPPLALVKLLKVLDRHPELLAEVRS

Nucleotide

• Length: 399 bp

>AT76543 NZ_CP021361:c2545122-2544724 [Acidovorax carolinensis]
ATGAAATGTCCTGTCTGCGGCGCAGCCGAACTCATTCACGATACCCGCGATGAAACCTACACCTACAAGGGTGAAAGCAC
CGTCATCCCCGCCGTGACAGGCGACTTCTGCCCGGCCTGCGATGAATCCTTGCTCGACCCGGCCGAGACCGAACGCGTCA
TGCGCGAGATGCGTGCCTTCACCCAGCAGGTCAACGCCGCCTTCGTCGCCCCCGGCTACATCACCGAGGTGCGCAAAAAG
CTCGCGCTCGACCAGCGCGAGGCCGCCGAAATATTTGGCGGCGGCGTCAACGCCTTCTCGCGCTACGAAACCGGCAAAAC
CCGGCCCCCGCTGGCGCTGGTCAAGCTGCTCAAGGTGCTCGACCGCCACCCCGAGCTGCTGGCCGAGGTGCGGTCATAA