Detailed information of TA system TA076540

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2511580..2512276
• Replicon: chromosome
• Accession: NZ_CP021359
• Organism: Acidovorax carolinensis strain NA2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CBP33_RS11765
• Protein ID: WP_086912711.1
• Coordinates: 2511980..2512276 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: CBP33_RS11760
• Protein ID: WP_086912710.1
• Coordinates: 2511580..2511978 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBP33_RS11735	2506700..2508433	-	1734	WP_086912706.1	Kef family K(+) transporter	-
CBP33_RS11745	2508750..2510444	-	1695	WP_162290796.1	restriction endonuclease subunit S	-
CBP33_RS11750	2510456..2510914	-	459	WP_086912708.1	hypothetical protein	-
CBP33_RS11755	2510907..2511494	-	588	WP_086912709.1	nucleotidyltransferase domain-containing protein	-
CBP33_RS11760	2511580..2511978	-	399	WP_086912710.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CBP33_RS11765	2511980..2512276	-	297	WP_086912711.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CBP33_RS11770	2512295..2513761	-	1467	WP_086912712.1	type I restriction-modification system subunit M	-
CBP33_RS11775	2513851..2516328	-	2478	WP_086912713.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10894.64 Da
• Isoelectric Point: 8.0518

>T76540 WP_086912711.1 NZ_CP021359:c2512276-2511980 [Acidovorax carolinensis]
MEKSTPHCKLTVVKALLQAGKFRVTRSARTGAEAMGIDFQGMLTVISALQASDFYKSMTTHADHTIWQDVYRTSSPLGDV
YLKLTVVDDLLIVSFKEL

Nucleotide

• Length: 297 bp

>T76540 NZ_CP021359:c2512276-2511980 [Acidovorax carolinensis]
ATGGAAAAGAGCACACCGCATTGCAAGCTGACCGTCGTCAAGGCCCTGCTGCAAGCTGGCAAGTTTCGCGTGACGCGTTC
AGCGCGCACCGGGGCAGAGGCCATGGGCATCGACTTCCAAGGCATGCTGACCGTGATTTCGGCGCTGCAGGCGTCAGACT
TTTATAAAAGCATGACCACCCATGCCGACCACACCATCTGGCAAGACGTGTACCGCACCAGCTCGCCGCTGGGGGATGTC
TATCTCAAGTTGACCGTGGTCGATGACCTGCTGATCGTGTCTTTCAAGGAGCTATGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14602.74 Da
• Isoelectric Point: 5.2741

>AT76540 WP_086912710.1 NZ_CP021359:c2511978-2511580 [Acidovorax carolinensis]
MKCPVCGAAELIHDTRDETYTYKGESTVIPAVTGDFCPACDESLLDPAETERVMREMRAFTQQVNAAFVAPGYITEVRKK
LALDQREAAEIFGGGVNAFSRYETGKTRPPLALVKLLKVLDRHPELLAEVRS

Nucleotide

• Length: 399 bp

>AT76540 NZ_CP021359:c2511978-2511580 [Acidovorax carolinensis]
ATGAAATGTCCTGTCTGCGGCGCAGCCGAACTCATTCACGATACCCGCGATGAAACCTACACCTACAAGGGTGAAAGCAC
CGTCATCCCCGCCGTGACAGGCGACTTCTGCCCGGCCTGCGATGAATCCTTGCTCGACCCGGCCGAGACCGAACGCGTCA
TGCGCGAGATGCGTGCCTTCACCCAGCAGGTCAACGCCGCCTTCGTCGCCCCCGGCTACATCACCGAGGTGCGCAAAAAG
CTCGCGCTCGACCAGCGCGAGGCCGCCGAAATTTTTGGCGGCGGCGTCAACGCCTTCTCGCGCTACGAAACCGGCAAAAC
CCGGCCCCCGCTGGCGCTGGTGAAACTGCTCAAGGTGCTCGACCGCCACCCCGAGCTGCTGGCCGAGGTGCGGTCATAA