Detailed information of TA system TA076535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1854078..1854577
• Replicon: chromosome
• Accession: NZ_CP021354
• Organism: Rhodococcus sp. S2-17

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CBI38_RS08940
• Protein ID: WP_109328189.1
• Coordinates: 1854078..1854332 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CBI38_RS08945
• Protein ID: WP_109328191.1
• Coordinates: 1854329..1854577 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI38_RS08920	1850303..1850650	+	348	WP_109328183.1	hypothetical protein	-
CBI38_RS08925	1850883..1852052	-	1170	WP_109328185.1	type IV secretion protein Rhs	-
CBI38_RS08935	1853106..1853378	-	273	WP_109328187.1	hypothetical protein	-
CBI38_RS37765	1853663..1853947	-	285	Protein_1742	excalibur calcium-binding domain-containing protein	-
CBI38_RS08940	1854078..1854332	-	255	WP_109328189.1	Txe/YoeB family addiction module toxin	Toxin
CBI38_RS08945	1854329..1854577	-	249	WP_109328191.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CBI38_RS08955	1855117..1856298	+	1182	WP_109328194.1	thiolase family protein	-
CBI38_RS08960	1856310..1857458	+	1149	WP_109328196.1	acyl-CoA dehydrogenase family protein	-
CBI38_RS08965	1857439..1858917	-	1479	WP_109328198.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10068.31 Da
• Isoelectric Point: 7.4659

>T76535 WP_109328189.1 NZ_CP021354:c1854332-1854078 [Rhodococcus sp. S2-17]
VNTASTDDGWEDYTHWSITDRKILKKINDLIKDIKRSPYEGIGKPERLRHIDDNVWSRRITQEHRLVYVIVDDTVVIQQA
RHHY

Nucleotide

• Length: 255 bp

>T76535 NZ_CP021354:c1854332-1854078 [Rhodococcus sp. S2-17]
GTGAACACCGCCTCCACCGACGACGGGTGGGAGGACTACACCCACTGGTCGATCACCGACCGCAAAATTCTGAAGAAGAT
CAACGACCTGATCAAAGACATCAAGCGGTCACCCTACGAAGGCATCGGGAAGCCCGAACGCCTCCGCCACATCGACGACA
ACGTCTGGTCCCGGCGCATCACCCAGGAACACCGGTTGGTGTACGTGATCGTCGACGACACAGTCGTCATCCAGCAAGCC
CGCCACCACTACTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9233.44 Da
• Isoelectric Point: 5.8315

>AT76535 WP_109328191.1 NZ_CP021354:c1854577-1854329 [Rhodococcus sp. S2-17]
MTAITATEARKNLFGLVSQVNKDHTIVEIVSKNGNAVLLSKDDYDSIMETAYLLSSPANARRLFRSLEATRRGEYTEREL
IE

Nucleotide

• Length: 249 bp

>AT76535 NZ_CP021354:c1854577-1854329 [Rhodococcus sp. S2-17]
ATGACTGCAATAACAGCCACCGAGGCCAGGAAGAACCTGTTCGGCTTGGTCAGCCAAGTGAACAAGGACCACACAATCGT
GGAAATAGTCTCCAAGAACGGGAACGCTGTTCTTCTCTCGAAGGACGACTACGACTCCATCATGGAAACGGCCTACCTGC
TGTCCAGCCCGGCGAACGCTCGCCGCCTGTTTCGCAGTCTGGAGGCAACCCGGCGCGGTGAATACACCGAAAGGGAACTG
ATCGAGTGA