76393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2608826..2610069 Replicon chromosome
Accession NZ_CP021283
Organism Legionella pneumophila subsp. pneumophila strain Allentown

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA921_RS11700 Protein ID WP_061692642.1
Coordinates 2609131..2610069 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA921_RS11695 Protein ID WP_061692643.1
Coordinates 2608826..2609134 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA921_RS11675 2605161..2606156 - 996 Protein_2251 transposase -
CA921_RS11680 2606224..2607507 - 1284 Protein_2252 DUF927 domain-containing protein -
CA921_RS11685 2607574..2607849 - 276 WP_061692644.1 DNA-binding protein -
CA921_RS11690 2608602..2608829 + 228 WP_027265543.1 helix-turn-helix transcriptional regulator -
CA921_RS11695 2608826..2609134 + 309 WP_061692643.1 HipA N-terminal domain-containing protein Antitoxin
CA921_RS11700 2609131..2610069 + 939 WP_061692642.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA921_RS11705 2610066..2611298 - 1233 WP_061692641.1 integrase family protein -
CA921_RS11710 2612511..2615069 - 2559 WP_061692640.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36080.86 Da        Isoelectric Point: 9.1296

>T76393 WP_061692642.1 NZ_CP021283:2609131-2610069 [Legionella pneumophila subsp. pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLDQRCKRFNFFD

Download         Length: 939 bp

>T76393 NZ_CP021283:2609131-2610069 [Legionella pneumophila subsp. pneumophila]
ATGAAACACTGTCCTATTACTTATGAAAAGATAAGTGTTCAAGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCCCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGTGTAGGAAAGATGT
CTATTCAAGGCGTTCAAAAGAAACTAAGTGCCAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACTTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAGTCATACAGCAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCTTTGCCTCTGAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTCGATCAGCGATGCAAGCGATTCAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11598.44 Da        Isoelectric Point: 4.6128

>AT76393 WP_061692643.1 NZ_CP021283:2608826-2609134 [Legionella pneumophila subsp. pneumophila]
MRKAYVSVNGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYEFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT76393 NZ_CP021283:2608826-2609134 [Legionella pneumophila subsp. pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGAATTTGACGTATTTC
CCCCTTTTTTTGAAGGATTACTCCCTGAAGGCATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAATTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References