76378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2764569..2765812 Replicon chromosome
Accession NZ_CP021272
Organism Legionella pneumophila strain D-5265

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA939_RS12640 Protein ID WP_106195130.1
Coordinates 2764874..2765812 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA939_RS12635 Protein ID WP_106195127.1
Coordinates 2764569..2764877 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA939_RS12610 2759631..2761142 + 1512 WP_106195112.1 Fic family protein -
CA939_RS12615 2761368..2761793 - 426 WP_106195115.1 hypothetical protein -
CA939_RS12620 2762078..2763667 - 1590 WP_106195118.1 Fic family protein -
CA939_RS12625 2763898..2764107 + 210 WP_106195121.1 hypothetical protein -
CA939_RS12630 2764345..2764572 + 228 WP_106195124.1 helix-turn-helix transcriptional regulator -
CA939_RS12635 2764569..2764877 + 309 WP_106195127.1 HipA N-terminal domain-containing protein Antitoxin
CA939_RS12640 2764874..2765812 + 939 WP_106195130.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA939_RS12645 2765809..2767042 - 1234 Protein_2444 integrase family protein -
CA939_RS12650 2767506..2768186 + 681 WP_062728057.1 hydrolase -
CA939_RS12655 2768257..2770098 + 1842 WP_106184168.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lpg2370 2756230..2767042 10812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36152.88 Da        Isoelectric Point: 9.1475

>T76378 WP_106195130.1 NZ_CP021272:2764874-2765812 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQNVIDGIVQEFHQVIPKWQELIDFSFLSQEMQEKYLELLDQRCKRFNFFD

Download         Length: 939 bp

>T76378 NZ_CP021272:2764874-2765812 [Legionella pneumophila]
ATGAAACGCTGCCCCATTACTTATGAAAAAATCAGTGACCAGGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAACGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGTGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTGACCTACTTCATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAGTCATACAGCAGTTTTGTACATTCCCAAAAATTGAATTCGTAAAATTATTTAAGCTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCATATGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCTTTGCCTCTGAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGATTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTCGATCAGCGATGCAAGCGATTCAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11582.43 Da        Isoelectric Point: 4.5556

>AT76378 WP_106195127.1 NZ_CP021272:2764569-2764877 [Legionella pneumophila]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYLGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT76378 NZ_CP021272:2764569-2764877 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCTGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAC
TATTTTGGCCAATTGATAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References