76375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2627769..2629012 Replicon chromosome
Accession NZ_CP021270
Organism Legionella pneumophila strain D-7787

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA940_RS11875 Protein ID WP_106184166.1
Coordinates 2628074..2629012 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA940_RS11870 Protein ID WP_061692643.1
Coordinates 2627769..2628077 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA940_RS11845 2623866..2624324 - 459 WP_106184163.1 hypothetical protein -
CA940_RS11850 2624791..2626542 - 1752 WP_106184164.1 DUF927 domain-containing protein -
CA940_RS11855 2626626..2626901 - 276 WP_027222465.1 helix-turn-helix domain-containing protein -
CA940_RS11865 2627545..2627772 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
CA940_RS11870 2627769..2628077 + 309 WP_061692643.1 HipA N-terminal domain-containing protein Antitoxin
CA940_RS11875 2628074..2629012 + 939 WP_106184166.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA940_RS11880 2629009..2630241 - 1233 WP_106184167.1 integrase family protein -
CA940_RS11885 2630705..2631385 + 681 WP_062728057.1 hydrolase -
CA940_RS11890 2631456..2633297 + 1842 WP_106184168.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36050.83 Da        Isoelectric Point: 9.1296

>T76375 WP_106184166.1 NZ_CP021270:2628074-2629012 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLALFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLDQRCKRFNFFD

Download         Length: 939 bp

>T76375 NZ_CP021270:2628074-2629012 [Legionella pneumophila]
ATGAAACACTGTCCTATTACTTATGAAAAGATAAGTGTTCAAGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCCCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGTGTAGGAAAGATGT
CTATTCAAGGCGTTCAAAAGAAACTAAGTGCCAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACTTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAGTCATACAGCAGTTTTGTACATTCCCAAAAATTGAATTCGTAAAATTATTTAAGCTGGC
GTTGTTTAACTTCCTGGTCGGCAACGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCATATGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCTTTGCCTCTGAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTCGATCAGCGATGCAAGCGATTCAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11598.44 Da        Isoelectric Point: 4.6128

>AT76375 WP_061692643.1 NZ_CP021270:2627769-2628077 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYEFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT76375 NZ_CP021270:2627769-2628077 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGAATTTGACGTATTTC
CACCCTTTTTTGAAGGATTACTCCCTGAAGGCATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAATTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References