76371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2726111..2727354 Replicon chromosome
Accession NZ_CP021268
Organism Legionella pneumophila subsp. pneumophila strain Birmingham

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA922_RS12455 Protein ID WP_042754550.1
Coordinates 2726416..2727354 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA922_RS12450 Protein ID WP_027224429.1
Coordinates 2726111..2726419 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA922_RS12425 2721784..2721981 - 198 WP_014842401.1 hypothetical protein -
CA922_RS12430 2722001..2723227 - 1227 WP_015961555.1 MFS transporter -
CA922_RS12435 2723863..2724336 + 474 WP_027224431.1 hypothetical protein -
CA922_RS12440 2724526..2725443 + 918 WP_042754552.1 LysR family transcriptional regulator -
CA922_RS12445 2725887..2726114 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
CA922_RS12450 2726111..2726419 + 309 WP_027224429.1 HipA N-terminal domain-containing protein Antitoxin
CA922_RS12455 2726416..2727354 + 939 WP_042754550.1 HipA domain-containing protein Toxin
CA922_RS12460 2727517..2728227 - 711 WP_027225948.1 outer membrane beta-barrel protein -
CA922_RS12470 2728710..2729003 - 294 WP_042754549.1 SNARE domain-containing protein -
CA922_RS12475 2729031..2729933 - 903 WP_042754548.1 hypothetical protein -
CA922_RS12480 2730096..2731550 + 1455 WP_027225951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36063.60 Da        Isoelectric Point: 8.9515

>T76371 WP_042754550.1 NZ_CP021268:2726416-2727354 [Legionella pneumophila subsp. pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
EKNNLTKSDFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

>T76371 NZ_CP021268:2726416-2727354 [Legionella pneumophila subsp. pneumophila]
ATGAAACGCTGCCCCATTACTTATGAAAAAATCAGTGACCAAGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGACGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTGGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAACGAAGCCATTACCATGACCCTTGCAAAGAC
CATTGGACTTGAAGTGCCTGTTCATGGTTTAGTGTACTCTAAAGATAACAGTTTGACTTACTTCATTAAACGGTTTGATA
GAATAGGCCATAATAAAAAATTAGCTTTAGAAGATTTTGCACAGCTATCGGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAATCATAGAGCAGTTTTGCACGTTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
ATTGTTTAACTTCCTGGTCGGCAATGAAGACATGCACCTAAAAAATTTTTCTCTAATTACCAGGGATAGAAAAATTTCCA
TATCACCAGCATACGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCATTGCCCCTCAAAGGG
GAAAAAAATAATTTAACAAAGAGTGATTTTTTTAACTATTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCAA
TGGGATCGCACAAGAGTTTCATCAGGCAATACCAGAATGGCGAGAGTTGATTAGTTTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCCAATTGCTCGATCAACGATGCAAGAGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT76371 WP_027224429.1 NZ_CP021268:2726111-2726419 [Legionella pneumophila subsp. pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT76371 NZ_CP021268:2726111-2726419 [Legionella pneumophila subsp. pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATCAAGGCTGGAATATTAGAAGAATTACAAAGCGGAAAATATCAATTCAG
TTACTTTGATGATTATCACGGGGCACCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATGATTTTGATGTATTTC
CCCCTTTTTTTGAAGGGTTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATAATAGTTGGCCAGGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References