Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2688737..2689974 Replicon chromosome
Accession NZ_CP021266
Organism Legionella pneumophila subsp. pneumophila strain Knoxville

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA925_RS12170 Protein ID WP_027224428.1
Coordinates 2689042..2689974 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA925_RS12165 Protein ID WP_027224429.1
Coordinates 2688737..2689045 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA925_RS12140 2684423..2684620 - 198 WP_014842401.1 hypothetical protein -
CA925_RS12145 2684640..2685866 - 1227 WP_027224432.1 MFS transporter -
CA925_RS12150 2686501..2686974 + 474 WP_027224431.1 hypothetical protein -
CA925_RS12155 2687153..2688070 + 918 WP_027224430.1 LysR family transcriptional regulator -
CA925_RS12160 2688513..2688740 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
CA925_RS12165 2688737..2689045 + 309 WP_027224429.1 HipA N-terminal domain-containing protein Antitoxin
CA925_RS12170 2689042..2689974 + 933 WP_027224428.1 HipA domain-containing protein Toxin
CA925_RS12175 2690103..2692670 + 2568 WP_027224427.1 magnesium-translocating P-type ATPase -
CA925_RS12180 2692705..2693649 + 945 WP_027224426.1 flippase-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35780.41 Da        Isoelectric Point: 9.5904

>T76365 WP_027224428.1 NZ_CP021266:2689042-2689974 [Legionella pneumophila subsp. pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF

Download         Length: 933 bp

>T76365 NZ_CP021266:2689042-2689974 [Legionella pneumophila subsp. pneumophila]
ATGAAACGCTGCCCGATTACTTATGAAAAAATCAGTGACCAAGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATCTTTTGAAATCGTGGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAACGAAGCCATTACCATGACCCTTGCAAAGAC
CATTGGCCTTGAAGTGCCTGTTCATGGTTTAGTGTACTCTAAAGATAACAGTTTGACTTACTTCATTAAACGGTTTGATA
GAATAGGCCATAATAAAAAATTAGCTTTAGAAGATTTTGCACAGCTATCGGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAATCATAGAGCAGTTTTGCACGTTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
ATTGTTTAACTTCCTGGTCGGCAATGAAGACATGCACCTAAAAAATTTTTCTCTAATTACTAGGGATAGAAAAATTTCCA
TATCACCAGCATACGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCATTGCCCCTCAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAACTATTTTGCCGTTGAGAAATTAGGATTAAATCAGAACGTCATCAA
TGGGATCGCACAAGAGTTTCATCAGGCAATACCAGAATGGCGAGAGTTGATTAGTTTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCCAATTGCTCGATCAACGATGCAAGAGATTAAATTTTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT76365 WP_027224429.1 NZ_CP021266:2688737-2689045 [Legionella pneumophila subsp. pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT76365 NZ_CP021266:2688737-2689045 [Legionella pneumophila subsp. pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATCAAGGCTGGAATATTAGAAGAATTACAAAGCGGAAAATATCAATTCAG
TTACTTTGATGATTATCACGGGGCACCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATGATTTTGATGTATTTC
CCCCTTTTTTTGAAGGGTTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATAATAGTTGGCCAGGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References