Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 2667107..2668350 | Replicon | chromosome |
Accession | NZ_CP021263 | ||
Organism | Legionella pneumophila subsp. fraseri strain D-3137 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | A0A2S6EXA8 |
Locus tag | CA930_RS11955 | Protein ID | WP_027227417.1 |
Coordinates | 2667412..2668350 (+) | Length | 313 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | A0A2S6EX97 |
Locus tag | CA930_RS11950 | Protein ID | WP_027227416.1 |
Coordinates | 2667107..2667415 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CA930_RS11915 | 2662456..2663316 | + | 861 | WP_027227410.1 | DUF2608 domain-containing protein | - |
CA930_RS11920 | 2663668..2663932 | - | 265 | Protein_2306 | hypothetical protein | - |
CA930_RS11925 | 2663980..2664291 | - | 312 | WP_027227411.1 | cupin | - |
CA930_RS11930 | 2664307..2664555 | - | 249 | WP_031301595.1 | hypothetical protein | - |
CA930_RS11935 | 2664862..2665335 | + | 474 | WP_027227413.1 | hypothetical protein | - |
CA930_RS11940 | 2665525..2666442 | + | 918 | WP_027227414.1 | LysR family transcriptional regulator | - |
CA930_RS11945 | 2666883..2667110 | + | 228 | WP_027227415.1 | helix-turn-helix transcriptional regulator | - |
CA930_RS11950 | 2667107..2667415 | + | 309 | WP_027227416.1 | HipA N-terminal domain-containing protein | Antitoxin |
CA930_RS11955 | 2667412..2668350 | + | 939 | WP_027227417.1 | lpg2370 family Dot/Icm T4SS effector | Toxin |
CA930_RS11960 | 2668644..2669807 | + | 1164 | WP_027227418.1 | hypothetical protein | - |
CA930_RS11965 | 2669799..2670986 | - | 1188 | WP_027227419.1 | fatty acid desaturase | - |
CA930_RS11970 | 2671111..2671278 | - | 168 | WP_011214444.1 | DUF3309 domain-containing protein | - |
CA930_RS11975 | 2671877..2672233 | + | 357 | WP_063720028.1 | hypothetical protein | - |
CA930_RS11980 | 2672274..2672558 | - | 285 | Protein_2318 | hypothetical protein | - |
CA930_RS11985 | 2672602..2673243 | - | 642 | WP_027227422.1 | RsmD family RNA methyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36142.94 Da Isoelectric Point: 9.5859
>T76357 WP_027227417.1 NZ_CP021263:2667412-2668350 [Legionella pneumophila subsp. fraseri]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD
Download Length: 939 bp
>T76357 NZ_CP021263:2667412-2668350 [Legionella pneumophila subsp. fraseri]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11611.39 Da Isoelectric Point: 4.5556
>AT76357 WP_027227416.1 NZ_CP021263:2667107-2667415 [Legionella pneumophila subsp. fraseri]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR
Download Length: 309 bp
>AT76357 NZ_CP021263:2667107-2667415 [Legionella pneumophila subsp. fraseri]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S6EXA8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S6EX97 |