Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 2678656..2679896 | Replicon | chromosome |
Accession | NZ_CP021262 | ||
Organism | Legionella pneumophila subsp. pascullei strain U8W (D-7160) |
Toxin (Protein)
Gene name | HipT | Uniprot ID | A0A140J6I8 |
Locus tag | CA931_RS12130 | Protein ID | WP_027222482.1 |
Coordinates | 2678961..2679896 (+) | Length | 312 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | A0A140J6I7 |
Locus tag | CA931_RS12125 | Protein ID | WP_027222481.1 |
Coordinates | 2678656..2678964 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CA931_RS12090 | 2674128..2674988 | + | 861 | WP_011947276.1 | DUF2608 domain-containing protein | - |
CA931_RS12095 | 2675338..2675637 | - | 300 | WP_027222477.1 | hypothetical protein | - |
CA931_RS12100 | 2675648..2675959 | - | 312 | WP_011947278.1 | cupin | - |
CA931_RS12105 | 2675950..2676231 | - | 282 | WP_050598290.1 | hypothetical protein | - |
CA931_RS12110 | 2676407..2676880 | + | 474 | WP_027222478.1 | hypothetical protein | - |
CA931_RS12115 | 2677070..2677987 | + | 918 | WP_027222479.1 | LysR family transcriptional regulator | - |
CA931_RS12120 | 2678432..2678659 | + | 228 | WP_027222480.1 | helix-turn-helix transcriptional regulator | - |
CA931_RS12125 | 2678656..2678964 | + | 309 | WP_027222481.1 | HipA N-terminal domain-containing protein | Antitoxin |
CA931_RS12130 | 2678961..2679896 | + | 936 | WP_027222482.1 | HipA domain-containing protein | Toxin |
CA931_RS12140 | 2680198..2681343 | + | 1146 | WP_027222483.1 | hypothetical protein | - |
CA931_RS12145 | 2681353..2682540 | - | 1188 | WP_061773169.1 | fatty acid desaturase | - |
CA931_RS12150 | 2682665..2682832 | - | 168 | WP_011214444.1 | DUF3309 domain-containing protein | - |
CA931_RS15785 | 2682944..2683117 | + | 174 | WP_158272786.1 | hypothetical protein | - |
CA931_RS12155 | 2683289..2683645 | + | 357 | WP_027222484.1 | hypothetical protein | - |
CA931_RS12160 | 2683686..2684618 | - | 933 | WP_027222485.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 312 a.a. Molecular weight: 36037.79 Da Isoelectric Point: 9.3028
>T76355 WP_027222482.1 NZ_CP021262:2678961-2679896 [Legionella pneumophila subsp. pascullei]
MKRCPITYERISDQENYSQRGLYLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSANLKIKEGCFEIVDQNG
HYILKPQSDVYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIEVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF
MKRCPITYERISDQENYSQRGLYLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSANLKIKEGCFEIVDQNG
HYILKPQSDVYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIEVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF
Download Length: 936 bp
>T76355 NZ_CP021262:2678961-2679896 [Legionella pneumophila subsp. pascullei]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGTATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCCGATGAGCAGCGTCAGGAAGCAATCGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTTCAAAAGAAACTAAGTGCAAATCTAAAGATTAAAGAGGGATGTTTTGAAATCGTCGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATGTTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCAGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGAAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGATATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGCCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAAAATCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAGATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCAATTAAATTTTTTTTGA
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGTATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCCGATGAGCAGCGTCAGGAAGCAATCGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTTCAAAAGAAACTAAGTGCAAATCTAAAGATTAAAGAGGGATGTTTTGAAATCGTCGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATGTTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCAGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGAAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGATATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGCCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAAAATCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAGATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCAATTAAATTTTTTTTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11664.54 Da Isoelectric Point: 4.7719
>AT76355 WP_027222481.1 NZ_CP021262:2678656-2678964 [Legionella pneumophila subsp. pascullei]
MRKAYVSVNGIKAGILEELQGGKYQFTYFDDYQGAPVSLTMPLKNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR
MRKAYVSVNGIKAGILEELQGGKYQFTYFDDYQGAPVSLTMPLKNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR
Download Length: 309 bp
>AT76355 NZ_CP021262:2678656-2678964 [Legionella pneumophila subsp. pascullei]
ATGAGAAAAGCATATGTATCAGTGAATGGCATTAAGGCAGGAATATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
TTACTTTGATGATTATCAGGGTGCACCTGTTTCGCTCACAATGCCGTTGAAAAATAAAGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAGATAGATAGAAATGAC
TATTTTGGTCAATTGATAATAGTTGGCCAAGATGTCGTAGGCGCGGTGACTATTGAGGAACTAAGATGA
ATGAGAAAAGCATATGTATCAGTGAATGGCATTAAGGCAGGAATATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
TTACTTTGATGATTATCAGGGTGCACCTGTTTCGCTCACAATGCCGTTGAAAAATAAAGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAGATAGATAGAAATGAC
TATTTTGGTCAATTGATAATAGTTGGCCAAGATGTCGTAGGCGCGGTGACTATTGAGGAACTAAGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140J6I8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140J6I7 |