Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 109150..109754 Replicon chromosome
Accession NZ_CP021259
Organism Legionella pneumophila strain D-7708

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CA934_RS00535 Protein ID WP_106224695.1
Coordinates 109150..109476 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CA934_RS00540 Protein ID WP_106224696.1
Coordinates 109473..109754 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA934_RS00505 105045..105479 - 435 WP_106224690.1 hypothetical protein -
CA934_RS00510 105500..105970 - 471 WP_106224691.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CA934_RS00515 105972..106748 - 777 WP_106224692.1 type IV toxin-antitoxin system AbiEi family antitoxin -
CA934_RS15485 106886..107095 + 210 WP_152687493.1 DUF1016 family protein -
CA934_RS00520 107274..108254 + 981 WP_106224693.1 hypothetical protein -
CA934_RS00525 108245..108772 + 528 WP_106224694.1 hypothetical protein -
CA934_RS00535 109150..109476 + 327 WP_106224695.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA934_RS00540 109473..109754 + 282 WP_106224696.1 helix-turn-helix domain-containing protein Antitoxin
CA934_RS00545 109944..110504 - 561 WP_106224697.1 hypothetical protein -
CA934_RS00550 110446..111117 - 672 WP_106224698.1 hypothetical protein -
CA934_RS00555 111312..111869 + 558 WP_106224699.1 transposase -
CA934_RS00565 112062..113240 - 1179 WP_028378833.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-85)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12345.45 Da        Isoelectric Point: 9.4893

>T76347 WP_106224695.1 NZ_CP021259:109150-109476 [Legionella pneumophila]
VHWTVDFYNESVEEAILAMPPKIQARMIKLLELIETHGANLGPPHTEAMGNGLFEVRAKAQEGIGRSLYCYMKDKHIMVL
HAFVKKSTKTSKQELNLALQRKREVEKL

Download         Length: 327 bp

>T76347 NZ_CP021259:109150-109476 [Legionella pneumophila]
GTGCATTGGACTGTTGATTTTTATAATGAGTCTGTAGAGGAGGCTATCTTGGCAATGCCTCCAAAAATTCAGGCTCGAAT
GATTAAGCTTTTAGAGTTAATTGAAACGCATGGCGCCAATCTTGGGCCTCCCCATACAGAAGCGATGGGTAATGGCTTGT
TTGAAGTTCGTGCAAAAGCTCAGGAAGGCATTGGCCGATCGCTTTATTGTTATATGAAGGATAAGCATATTATGGTTTTA
CATGCTTTTGTAAAGAAAAGTACAAAAACCTCAAAGCAGGAATTAAATTTGGCTTTGCAGAGAAAGCGAGAGGTGGAAAA
ATTATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10540.10 Da        Isoelectric Point: 8.9613

>AT76347 WP_106224696.1 NZ_CP021259:109473-109754 [Legionella pneumophila]
MNLKTLKEKALKNEDLKQAYDELESEFALIDSLLSMRQKAGLTQEQLAERMGTQKGNISRLEKGSSNPSWKTLEKYAHAC
GFDISMAFKRIVS

Download         Length: 282 bp

>AT76347 NZ_CP021259:109473-109754 [Legionella pneumophila]
ATGAACCTTAAAACATTAAAAGAGAAAGCACTTAAAAATGAGGACCTAAAGCAAGCTTATGACGAATTAGAGTCAGAGTT
TGCATTGATTGACTCATTACTTTCGATGCGTCAAAAAGCCGGATTAACTCAAGAACAGCTTGCAGAGCGCATGGGTACAC
AAAAAGGAAACATTTCTCGATTGGAGAAAGGGAGCAGCAACCCAAGCTGGAAAACATTGGAAAAATACGCCCATGCCTGT
GGTTTTGATATCTCCATGGCATTTAAGCGAATTGTGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References