76346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2677452..2678695 Replicon chromosome
Accession NZ_CP021258
Organism Legionella pneumophila subsp. fraseri strain D-5744

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag CA935_RS11965 Protein ID WP_027227417.1
Coordinates 2677757..2678695 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag CA935_RS11960 Protein ID WP_027227416.1
Coordinates 2677452..2677760 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA935_RS11925 2672801..2673661 + 861 WP_027227410.1 DUF2608 domain-containing protein -
CA935_RS11930 2674013..2674277 - 265 Protein_2310 hypothetical protein -
CA935_RS11935 2674325..2674636 - 312 WP_027227411.1 cupin -
CA935_RS11940 2674652..2674900 - 249 WP_031301595.1 hypothetical protein -
CA935_RS11945 2675207..2675680 + 474 WP_027227413.1 hypothetical protein -
CA935_RS11950 2675870..2676787 + 918 WP_027227414.1 LysR family transcriptional regulator -
CA935_RS11955 2677228..2677455 + 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
CA935_RS11960 2677452..2677760 + 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
CA935_RS11965 2677757..2678695 + 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA935_RS11970 2678989..2680152 + 1164 WP_027227418.1 hypothetical protein -
CA935_RS11975 2680144..2681331 - 1188 WP_027227419.1 fatty acid desaturase -
CA935_RS11980 2681456..2681623 - 168 WP_011214444.1 DUF3309 domain-containing protein -
CA935_RS11985 2682222..2682578 + 357 WP_063720028.1 hypothetical protein -
CA935_RS11990 2682619..2682903 - 285 Protein_2322 hypothetical protein -
CA935_RS11995 2682947..2683588 - 642 WP_027227422.1 RsmD family RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T76346 WP_027227417.1 NZ_CP021258:2677757-2678695 [Legionella pneumophila subsp. fraseri]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T76346 NZ_CP021258:2677757-2678695 [Legionella pneumophila subsp. fraseri]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT76346 WP_027227416.1 NZ_CP021258:2677452-2677760 [Legionella pneumophila subsp. fraseri]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT76346 NZ_CP021258:2677452-2677760 [Legionella pneumophila subsp. fraseri]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References