76342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 626776..628019 Replicon chromosome
Accession NZ_CP021257
Organism Legionella pneumophila subsp. fraseri strain Lansing 3

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag CA936_RS02795 Protein ID WP_027227417.1
Coordinates 626776..627714 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag CA936_RS02800 Protein ID WP_027227416.1
Coordinates 627711..628019 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA936_RS02765 621883..622524 + 642 WP_027227422.1 RsmD family RNA methyltransferase -
CA936_RS02770 622568..622852 + 285 Protein_534 hypothetical protein -
CA936_RS02775 622893..623249 - 357 WP_063720028.1 hypothetical protein -
CA936_RS02780 623848..624015 + 168 WP_011214444.1 DUF3309 domain-containing protein -
CA936_RS02785 624140..625327 + 1188 WP_027227419.1 fatty acid desaturase -
CA936_RS02790 625319..626482 - 1164 WP_028378585.1 hypothetical protein -
CA936_RS02795 626776..627714 - 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA936_RS02800 627711..628019 - 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
CA936_RS02805 628016..628243 - 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
CA936_RS02810 628684..629601 - 918 WP_027227414.1 LysR family transcriptional regulator -
CA936_RS02815 629791..630264 - 474 WP_027227413.1 hypothetical protein -
CA936_RS02820 630571..630819 + 249 WP_031301595.1 hypothetical protein -
CA936_RS02825 630835..631146 + 312 WP_027227411.1 cupin -
CA936_RS02830 631194..631458 + 265 Protein_546 hypothetical protein -
CA936_RS02835 632037..632783 - 747 WP_028378828.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T76342 WP_027227417.1 NZ_CP021257:c627714-626776 [Legionella pneumophila subsp. fraseri]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T76342 NZ_CP021257:c627714-626776 [Legionella pneumophila subsp. fraseri]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT76342 WP_027227416.1 NZ_CP021257:c628019-627711 [Legionella pneumophila subsp. fraseri]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT76342 NZ_CP021257:c628019-627711 [Legionella pneumophila subsp. fraseri]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References