Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1711658..1712238 Replicon chromosome
Accession NZ_CP021248
Organism Novosphingobium sp. KA1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CA833_RS25110 Protein ID WP_207080593.1
Coordinates 1711658..1711939 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag CA833_RS25115 Protein ID WP_207081329.1
Coordinates 1711957..1712238 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA833_RS25095 1706751..1708088 + 1338 WP_207080590.1 dGTPase -
CA833_RS25100 1708146..1708718 - 573 WP_207080591.1 hypothetical protein -
CA833_RS25105 1709380..1710918 - 1539 WP_207080592.1 DUF1593 domain-containing protein -
CA833_RS25110 1711658..1711939 + 282 WP_207080593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA833_RS25115 1711957..1712238 + 282 WP_207081329.1 HigA family addiction module antidote protein Antitoxin
CA833_RS25120 1712689..1712901 - 213 Protein_1447 transposase -
CA833_RS25125 1713827..1715773 + 1947 WP_207080594.1 hypothetical protein -
CA833_RS25130 1715981..1716658 - 678 Protein_1449 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10533.96 Da        Isoelectric Point: 5.1116

>T76336 WP_207080593.1 NZ_CP021248:1711658-1711939 [Novosphingobium sp. KA1]
MIQSAKGKLVEQVLAGKPEKGFPNDIFRAALRKIAMLEAAVNLDDLRSPPGNRLEALSDDREGQHSIRINDQWRICFVWT
DSGPQDVEIMDYH

Download         Length: 282 bp

>T76336 NZ_CP021248:1711658-1711939 [Novosphingobium sp. KA1]
ATGATACAGAGCGCCAAGGGCAAGTTGGTTGAACAAGTCTTGGCGGGCAAGCCGGAAAAGGGCTTCCCGAATGACATCTT
CCGGGCCGCTTTGCGGAAAATAGCCATGCTTGAGGCAGCGGTAAATCTGGACGATCTGCGGTCGCCTCCAGGCAACAGGC
TAGAAGCCCTGTCCGATGACCGTGAGGGCCAGCATTCGATCCGTATCAACGACCAATGGCGTATCTGTTTCGTCTGGACC
GACAGCGGCCCGCAAGACGTAGAGATCATGGACTATCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10537.24 Da        Isoelectric Point: 6.6405

>AT76336 WP_207081329.1 NZ_CP021248:1711957-1712238 [Novosphingobium sp. KA1]
MLKTPVHPGEILKHEFLEEMGISAGKLAKHIHVPRTRIERLCEERTSVTPDTAKRLSKALGTTPEFWLNLQTHYDLLVDQ
AADIEEIKPLLVA

Download         Length: 282 bp

>AT76336 NZ_CP021248:1711957-1712238 [Novosphingobium sp. KA1]
ATGTTGAAAACCCCGGTCCATCCCGGCGAAATCCTCAAGCATGAGTTCCTTGAGGAGATGGGCATTTCTGCTGGCAAGCT
GGCGAAGCATATCCATGTTCCTCGCACCCGCATCGAACGACTGTGCGAGGAGAGGACTTCGGTCACGCCGGACACTGCCA
AGCGTCTATCCAAGGCACTTGGTACGACGCCGGAGTTCTGGCTTAACCTCCAGACGCATTATGATTTGCTGGTGGATCAG
GCAGCGGACATTGAGGAAATCAAGCCGTTGCTGGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References