Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 79715..80372 | Replicon | plasmid p1002-NDM1 |
| Accession | NZ_CP021206 | ||
| Organism | Escherichia coli strain Z1002 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | CA268_RS29530 | Protein ID | WP_000270043.1 |
| Coordinates | 79715..80065 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CA268_RS29535 | Protein ID | WP_000124640.1 |
| Coordinates | 80070..80372 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA268_RS29490 | 76189..76686 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| CA268_RS29495 | 76689..77177 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| CA268_RS29500 | 77274..77609 | + | 336 | WP_000683477.1 | hypothetical protein | - |
| CA268_RS29505 | 77624..78094 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| CA268_RS29510 | 78087..78458 | - | 372 | WP_000516918.1 | hypothetical protein | - |
| CA268_RS29515 | 78469..78663 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| CA268_RS29525 | 79004..79552 | - | 549 | WP_001061573.1 | hypothetical protein | - |
| CA268_RS29530 | 79715..80065 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CA268_RS29535 | 80070..80372 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| CA268_RS29540 | 80399..80692 | - | 294 | WP_001239998.1 | hypothetical protein | - |
| CA268_RS29545 | 80781..81053 | - | 273 | WP_001043046.1 | HU family DNA-binding protein | - |
| CA268_RS29550 | 81111..81638 | - | 528 | WP_004201083.1 | thermonuclease family protein | - |
| CA268_RS30765 | 81641..81946 | - | 306 | WP_171820680.1 | hypothetical protein | - |
| CA268_RS29560 | 81858..82715 | - | 858 | WP_001167036.1 | hypothetical protein | - |
| CA268_RS29565 | 82702..82932 | - | 231 | WP_000972665.1 | hypothetical protein | - |
| CA268_RS29570 | 82932..83450 | - | 519 | WP_000210757.1 | nitrite reductase | - |
| CA268_RS29575 | 83447..83893 | - | 447 | WP_000919343.1 | hypothetical protein | - |
| CA268_RS29580 | 83893..84252 | - | 360 | WP_000422769.1 | hypothetical protein | - |
| CA268_RS29585 | 84310..84738 | - | 429 | WP_000591076.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaNDM-1 / rmtC / sul1 / qacE / mph(A) / aac(3)-IId / blaTEM-1B / blaCTX-M-14 | htpB | 1..111688 | 111688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T76272 WP_000270043.1 NZ_CP021206:79715-80065 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T76272 NZ_CP021206:79715-80065 [Escherichia coli]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT76272 WP_000124640.1 NZ_CP021206:80070-80372 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT76272 NZ_CP021206:80070-80372 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|