Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5066299..5067098 Replicon chromosome
Accession NZ_CP021202
Organism Escherichia coli strain Z1002

Toxin (Protein)


Gene name yhaV Uniprot ID D3GWU5
Locus tag CA268_RS26090 Protein ID WP_000347272.1
Coordinates 5066634..5067098 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag CA268_RS26085 Protein ID WP_001307405.1
Coordinates 5066299..5066634 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA268_RS26070 5062084..5062854 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
CA268_RS26075 5062870..5064204 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
CA268_RS26080 5064579..5066150 + 1572 WP_001273738.1 galactarate dehydratase -
CA268_RS26085 5066299..5066634 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
CA268_RS26090 5066634..5067098 + 465 WP_000347272.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
CA268_RS26095 5067153..5067962 - 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
CA268_RS26105 5068211..5069491 + 1281 WP_001521382.1 tagatose-bisphosphate aldolase subunit KbaZ -
CA268_RS26110 5069514..5069987 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
CA268_RS26115 5069998..5070777 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
CA268_RS26120 5070767..5071645 + 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CA268_RS26125 5071663..5072097 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5056774..5067098 10324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17832.26 Da        Isoelectric Point: 9.6924

>T76259 WP_000347272.1 NZ_CP021202:5066634-5067098 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

>T76259 NZ_CP021202:5066634-5067098 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT76259 WP_001307405.1 NZ_CP021202:5066299-5066634 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT76259 NZ_CP021202:5066299-5066634 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829KUD2


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References