76258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4958592..4959285 Replicon chromosome
Accession NZ_CP021202
Organism Escherichia coli strain Z1002

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CA268_RS25510 Protein ID WP_000415584.1
Coordinates 4958989..4959285 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CA268_RS25505 Protein ID WP_000650107.1
Coordinates 4958592..4958987 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA268_RS25495 4954456..4956714 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
CA268_RS25500 4956852..4958459 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
CA268_RS25505 4958592..4958987 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CA268_RS25510 4958989..4959285 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CA268_RS25515 4959490..4959972 - 483 WP_000183505.1 transcriptional regulator -
CA268_RS25520 4960025..4960417 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CA268_RS25525 4960569..4961228 + 660 WP_001221493.1 two-component system response regulator QseB -
CA268_RS25530 4961225..4962574 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
CA268_RS25535 4962620..4962952 - 333 WP_023149630.1 DUF2645 family protein -
CA268_RS25545 4963271..4963852 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CA268_RS25550 4963883..4964197 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T76258 WP_000415584.1 NZ_CP021202:c4959285-4958989 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T76258 NZ_CP021202:c4959285-4958989 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT76258 WP_000650107.1 NZ_CP021202:c4958987-4958592 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT76258 NZ_CP021202:c4958987-4958592 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References