Detailed information of TA system TA076239

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2936764..2937135
• Replicon: chromosome
• Accession: NZ_CP021202
• Organism: Escherichia coli strain Z1002

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: CA268_RS15115
• Protein ID: WP_001443846.1
• Coordinates: 2936986..2937135 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2936764..2936942 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA268_RS15090	2932719..2934092	+	1374	WP_000123748.1	ATP-dependent RNA helicase DbpA	-
CA268_RS15095	2934221..2935156	-	936	WP_001523172.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
CA268_RS15100	2935208..2936443	-	1236	WP_000040839.1	site-specific integrase	-
CA268_RS15105	2936445..2936660	-	216	WP_000079604.1	excisionase XisR	-
CA268_RS15110	2936760..2936948	-	189	WP_001302840.1	DUF1187 family protein	-
-	2936764..2936942	+	179	NuclAT_0	-	Antitoxin
-	2936764..2936942	+	179	NuclAT_0	-	Antitoxin
-	2936764..2936942	+	179	NuclAT_0	-	Antitoxin
-	2936764..2936942	+	179	NuclAT_0	-	Antitoxin
CA268_RS15115	2936986..2937135	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
CA268_RS15120	2937191..2938000	-	810	WP_000166313.1	recombination protein RecT	-
CA268_RS15125	2937993..2940593	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
CA268_RS15130	2940695..2940970	-	276	WP_001344816.1	hypothetical protein	-
CA268_RS15135	2941045..2941215	-	171	WP_001352098.1	conserved protein, Rac prophage	-
CA268_RS15140	2941215..2941436	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2935208..2981590	46382

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T76239 WP_001443846.1 NZ_CP021202:c2937135-2936986 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T76239 NZ_CP021202:c2937135-2936986 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT76239 NZ_CP021202:2936764-2936942 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin