Detailed information of TA system TA076185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2108689..2108906
• Replicon: chromosome
• Accession: NZ_CP021178
• Organism: Staphylococcus aureus subsp. aureus ST398 strain 2012-3

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CAC37_RS10355
• Protein ID: WP_001802298.1
• Coordinates: 2108802..2108906 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2108689..2108744 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAC37_RS10330	2104828..2105493	-	666	WP_001024099.1	SDR family oxidoreductase	-
CAC37_RS10335	2105645..2105965	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CAC37_RS10340	2105967..2106947	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
CAC37_RS10345	2107213..2108304	+	1092	WP_000495673.1	hypothetical protein	-
-	2108689..2108744	+	56	-	-	Antitoxin
CAC37_RS10355	2108802..2108906	-	105	WP_001802298.1	hypothetical protein	Toxin
CAC37_RS10360	2109586..2109744	+	159	WP_001792784.1	hypothetical protein	-
CAC37_RS10365	2110180..2110272	+	93	WP_000220902.1	hypothetical protein	-
CAC37_RS10370	2110402..2111259	-	858	WP_000370942.1	HAD family hydrolase	-
CAC37_RS10375	2111327..2112109	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
CAC37_RS10380	2112399..2113007	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T76185 WP_001802298.1 NZ_CP021178:c2108906-2108802 [Staphylococcus aureus subsp. aureus ST398]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T76185 NZ_CP021178:c2108906-2108802 [Staphylococcus aureus subsp. aureus ST398]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT76185 NZ_CP021178:2108689-2108744 [Staphylococcus aureus subsp. aureus ST398]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin