76146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2457407..2457591 Replicon chromosome
Accession NZ_CP021171
Organism Staphylococcus aureus strain CHU15-056

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag B5M25_RS12855 Protein ID WP_000482652.1
Coordinates 2457484..2457591 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2457407..2457467 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5M25_RS12830 2452862..2453029 - 168 Protein_2372 hypothetical protein -
B5M25_RS12840 2453260..2454993 - 1734 WP_057485187.1 ABC transporter ATP-binding protein/permease -
B5M25_RS12845 2455018..2456781 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2457407..2457467 + 61 - - Antitoxin
B5M25_RS12855 2457484..2457591 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
B5M25_RS12860 2457725..2458111 - 387 WP_000779360.1 flippase GtxA -
B5M25_RS12865 2458379..2459521 + 1143 WP_001176863.1 glycerate kinase -
B5M25_RS12870 2459581..2460240 + 660 WP_000831298.1 membrane protein -
B5M25_RS12875 2460422..2461633 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
B5M25_RS12880 2461756..2462229 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T76146 WP_000482652.1 NZ_CP021171:c2457591-2457484 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T76146 NZ_CP021171:c2457591-2457484 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT76146 NZ_CP021171:2457407-2457467 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References