Detailed information of TA system TA076138

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2001488..2001795
• Replicon: chromosome
• Accession: NZ_CP021171
• Organism: Staphylococcus aureus strain CHU15-056

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: B5M25_RS10310
• Protein ID: WP_011447039.1
• Coordinates: 2001619..2001795 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2001488..2001627 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5M25_RS10250	1997054..1997233	+	180	WP_000669791.1	hypothetical protein	-
B5M25_RS10260	1997544..1997804	+	261	WP_001791826.1	hypothetical protein	-
B5M25_RS10265	1997857..1998207	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
B5M25_RS10270	1998718..1999053	-	336	Protein_1896	SH3 domain-containing protein	-
B5M25_RS10290	1999704..2000195	-	492	WP_000920038.1	staphylokinase	-
B5M25_RS10295	2000386..2001141	-	756	WP_000861038.1	CHAP domain-containing protein	-
B5M25_RS10300	2001153..2001407	-	255	WP_000611512.1	phage holin	-
B5M25_RS10305	2001459..2001566	+	108	WP_031762631.1	hypothetical protein	-
-	2001488..2001627	+	140	NuclAT_0	-	Antitoxin
-	2001488..2001627	+	140	NuclAT_0	-	Antitoxin
-	2001488..2001627	+	140	NuclAT_0	-	Antitoxin
-	2001488..2001627	+	140	NuclAT_0	-	Antitoxin
B5M25_RS10310	2001619..2001795	-	177	WP_011447039.1	putative holin-like toxin	Toxin
B5M25_RS10315	2001929..2002681	-	753	WP_204163314.1	staphylococcal enterotoxin type P	-
B5M25_RS10320	2003060..2003434	-	375	WP_000340977.1	hypothetical protein	-
B5M25_RS10325	2003490..2003777	-	288	WP_001040255.1	hypothetical protein	-
B5M25_RS10330	2003824..2003976	-	153	WP_000654329.1	hypothetical protein	-
B5M25_RS14505	2003966..2004286	-	321	WP_204163311.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1997857..2046023	48166

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T76138 WP_011447039.1 NZ_CP021171:c2001795-2001619 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T76138 NZ_CP021171:c2001795-2001619 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT76138 NZ_CP021171:2001488-2001627 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin