Detailed information of TA system TA076008

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1564478..1564803
• Replicon: chromosome
• Accession: NZ_CP021123
• Organism: Bacillus subtilis strain SEM-9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: CAH07_RS08170
• Protein ID: WP_004398662.1
• Coordinates: 1564624..1564803 (-)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1564478..1564700 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAH07_RS08125	1559847..1560158	+	312	WP_003229923.1	YqbF domain-containing protein	-
CAH07_RS08130	1560162..1560557	+	396	WP_004398566.1	DUF3199 family protein	-
CAH07_RS08135	1560554..1560916	+	363	WP_003229925.1	YqbH/XkdH family protein	-
CAH07_RS08140	1560913..1561416	+	504	WP_003246050.1	HK97 gp10 family phage protein	-
CAH07_RS08145	1561429..1561866	+	438	WP_003229927.1	hypothetical protein	-
CAH07_RS08150	1561863..1562054	+	192	WP_010886574.1	hypothetical protein	-
CAH07_RS08155	1562055..1563455	+	1401	WP_003229929.1	phage tail sheath family protein	-
CAH07_RS08160	1563458..1563901	+	444	WP_003229930.1	phage tail tube protein	-
CAH07_RS08165	1564155..1564244	-	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
-	1564478..1564700	+	223	NuclAT_0	-	Antitoxin
-	1564478..1564700	+	223	NuclAT_0	-	Antitoxin
-	1564478..1564700	+	223	NuclAT_0	-	Antitoxin
-	1564478..1564700	+	223	NuclAT_0	-	Antitoxin
CAH07_RS08170	1564624..1564803	-	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
CAH07_RS08175	1564949..1565398	+	450	WP_032722171.1	phage portal protein	-
CAH07_RS08180	1565440..1565577	+	138	WP_021480099.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1543800..1605504	61704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T76008 WP_004398662.1 NZ_CP021123:c1564803-1564624 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T76008 NZ_CP021123:c1564803-1564624 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT76008 NZ_CP021123:1564478-1564700 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin