Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2194627..2195237 Replicon chromosome
Accession NZ_CP021110
Organism Bordetella genomosp. 9 strain AU14267

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CAL14_RS10180 Protein ID WP_086057379.1
Coordinates 2194627..2194938 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CAL14_RS10185 Protein ID WP_086057380.1
Coordinates 2194941..2195237 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL14_RS10165 2190256..2191722 - 1467 WP_086057376.1 NAD(P)/FAD-dependent oxidoreductase -
CAL14_RS10170 2191719..2192702 - 984 WP_086057377.1 LysR family transcriptional regulator -
CAL14_RS20770 2192760..2192933 - 174 WP_157664450.1 hypothetical protein -
CAL14_RS10175 2193053..2194276 + 1224 WP_086057378.1 HPP family protein -
CAL14_RS10180 2194627..2194938 + 312 WP_086057379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAL14_RS10185 2194941..2195237 + 297 WP_086057380.1 helix-turn-helix domain-containing protein Antitoxin
CAL14_RS10190 2195251..2196054 - 804 WP_086057381.1 2,5-didehydrogluconate reductase DkgB -
CAL14_RS10195 2196384..2198012 + 1629 WP_086057382.1 Tar ligand binding domain-containing protein -
CAL14_RS10200 2198025..2199401 - 1377 WP_086057383.1 sulfite reductase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-78)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11787.59 Da        Isoelectric Point: 8.8384

>T75998 WP_086057379.1 NZ_CP021110:2194627-2194938 [Bordetella genomosp. 9]
MEFIETPVFTRSITSLLSDQEYAGLQQLLIENPERGDLIRGGGGIRKVRYGRQGIGKSGGIRVIYYWISEHHRIYMLAAY
PKCRKDDLTPAEISILRDFAKEL

Download         Length: 312 bp

>T75998 NZ_CP021110:2194627-2194938 [Bordetella genomosp. 9]
ATGGAATTCATAGAAACCCCGGTATTCACGAGGTCGATCACCTCGTTGTTGTCGGATCAGGAATATGCCGGGCTGCAGCA
GCTGCTGATTGAGAACCCCGAGCGGGGCGATCTCATTCGAGGTGGTGGCGGCATACGGAAGGTACGGTATGGTCGGCAAG
GCATTGGAAAAAGCGGCGGGATCCGGGTCATTTACTACTGGATCAGTGAACACCATCGGATCTACATGCTCGCGGCCTAT
CCAAAATGCAGGAAAGACGATCTGACACCCGCCGAGATTTCGATCCTGCGCGACTTCGCCAAGGAGCTGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11013.73 Da        Isoelectric Point: 10.9583

>AT75998 WP_086057380.1 NZ_CP021110:2194941-2195237 [Bordetella genomosp. 9]
MKKDDTLFDELRTSLKQAVAIRKGEMQPSRVFKVETIDVKATREKTRLSQREFAEAIQVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDVAVRALRA

Download         Length: 297 bp

>AT75998 NZ_CP021110:2194941-2195237 [Bordetella genomosp. 9]
ATGAAGAAAGACGATACGTTGTTCGACGAGCTTCGCACCAGTCTGAAGCAGGCAGTGGCCATCCGCAAAGGTGAGATGCA
GCCGTCGCGCGTGTTCAAGGTGGAGACGATTGACGTCAAGGCTACGCGTGAAAAAACGCGCTTGTCTCAAAGGGAATTTG
CCGAGGCGATCCAAGTCAGCGTCCGCACATTGCAGAACTGGGAGCAGGGGCATAGGAACCCGACTGGCCCGGCGGTTGCT
TTGTTGAAGATTGTGGCGAGCGCACCGGATGTCGCGGTGCGCGCGTTGCGAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References