Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2305726..2306336 Replicon chromosome
Accession NZ_CP021109
Organism Bordetella genomosp. 9 strain AU17164

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CAL13_RS10685 Protein ID WP_086072354.1
Coordinates 2305726..2306037 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CAL13_RS10690 Protein ID WP_086072355.1
Coordinates 2306040..2306336 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL13_RS10665 2301355..2302821 - 1467 WP_198297827.1 NAD(P)/FAD-dependent oxidoreductase -
CAL13_RS10670 2302818..2303801 - 984 WP_086057377.1 LysR family transcriptional regulator -
CAL13_RS10675 2303840..2304031 - 192 WP_157664844.1 hypothetical protein -
CAL13_RS10680 2304151..2305374 + 1224 WP_086072353.1 HPP family protein -
CAL13_RS10685 2305726..2306037 + 312 WP_086072354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CAL13_RS10690 2306040..2306336 + 297 WP_086072355.1 helix-turn-helix domain-containing protein Antitoxin
CAL13_RS10695 2306350..2307153 - 804 WP_086072356.1 2,5-didehydrogluconate reductase DkgB -
CAL13_RS10700 2307483..2309111 + 1629 WP_086072357.1 Tar ligand binding domain-containing protein -
CAL13_RS10705 2309124..2310506 - 1383 WP_086072358.1 sulfite reductase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-78)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11813.67 Da        Isoelectric Point: 8.8384

>T75995 WP_086072354.1 NZ_CP021109:2305726-2306037 [Bordetella genomosp. 9]
MEFIETPVFTRLISSLLSDQEYAGLQQLLIENPERGDLIRGGGGIRKVRYGRQGIGKSGGIRVIYYWISEHHRIYMLAAY
PKCRKDDLTPGEISILRDFVKEL

Download         Length: 312 bp

>T75995 NZ_CP021109:2305726-2306037 [Bordetella genomosp. 9]
ATGGAATTCATAGAAACCCCGGTATTCACGAGGTTGATCTCCTCGTTGTTGTCGGATCAGGAATATGCCGGGCTGCAGCA
GCTGCTGATTGAGAACCCCGAGCGGGGCGATCTCATTCGAGGCGGTGGCGGCATACGGAAGGTACGGTATGGTCGGCAAG
GCATTGGAAAAAGCGGCGGGATCCGGGTCATTTACTACTGGATCAGTGAACACCATCGGATCTACATGCTCGCGGCCTAT
CCAAAATGCAGGAAAGACGATCTGACACCCGGCGAGATTTCGATCCTGCGCGACTTCGTCAAGGAGCTGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10994.68 Da        Isoelectric Point: 10.7648

>AT75995 WP_086072355.1 NZ_CP021109:2306040-2306336 [Bordetella genomosp. 9]
MKKDDTLFDELHTSLKQAVAIRKGEMQPSRVFKVETIDVKATREKTRLSQREFAEAIQVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDVAVRALRA

Download         Length: 297 bp

>AT75995 NZ_CP021109:2306040-2306336 [Bordetella genomosp. 9]
ATGAAGAAAGACGATACGTTGTTCGACGAGCTTCACACCAGTCTGAAGCAGGCAGTGGCCATCCGCAAAGGTGAGATGCA
GCCGTCGCGCGTGTTCAAGGTGGAGACGATTGACGTCAAGGCTACGCGTGAAAAAACGCGCTTGTCTCAAAGGGAATTTG
CCGAGGCGATCCAAGTCAGCGTCCGCACATTGCAGAACTGGGAGCAGGGGCATAGGAACCCGACCGGCCCGGCGGTTGCT
TTGTTGAAGATTGTGGCGAGCGCACCGGATGTCGCGGTGCGCGCGTTGCGAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References