Detailed information of TA system TA075987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3667533..3668233
• Replicon: chromosome
• Accession: NZ_CP021107
• Organism: Bordetella genomosp. 6 strain AU22978

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CAL11_RS17185
• Protein ID: WP_086093621.1
• Coordinates: 3667937..3668233 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: CAL11_RS17180
• Protein ID: WP_086093620.1
• Coordinates: 3667533..3667934 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAL11_RS17155	3662733..3663755	-	1023	WP_086093615.1	amino acid ABC transporter substrate-binding protein	-
CAL11_RS17160	3663891..3664928	-	1038	WP_086093616.1	threonylcarbamoyl-AMP synthase	-
CAL11_RS17165	3664947..3666137	-	1191	WP_086093617.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CAL11_RS17170	3666140..3666655	-	516	WP_167382528.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CAL11_RS17175	3666790..3667269	-	480	WP_086093619.1	disulfide bond formation protein B	-
CAL11_RS24400	3667277..3667435	-	159	WP_167382416.1	hypothetical protein	-
CAL11_RS17180	3667533..3667934	-	402	WP_086093620.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CAL11_RS17185	3667937..3668233	-	297	WP_086093621.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CAL11_RS17190	3668433..3669314	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CAL11_RS17195	3669542..3669988	+	447	WP_033464956.1	GFA family protein	-
CAL11_RS17200	3670073..3671137	-	1065	WP_015064288.1	fructose-bisphosphate aldolase class II	-
CAL11_RS17205	3671313..3671855	-	543	WP_086093622.1	MOSC domain-containing protein	-
CAL11_RS17210	3672103..3673233	+	1131	WP_086093623.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-109)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10645.63 Da
• Isoelectric Point: 7.9330

>T75987 WP_086093621.1 NZ_CP021107:c3668233-3667937 [Bordetella genomosp. 6]
MEKGTPHCKLPALKALVHAGQVRATLSALSGAAALGLDFNAMIDIVLALTPRDFHKSMTTHADHRIWQDVYCPMTVMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T75987 NZ_CP021107:c3668233-3667937 [Bordetella genomosp. 6]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTTATC
GGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAACGCCATGATCGACATCGTGCTGGCGCTGACACCGCGGGATT
TCCACAAAAGCATGACGACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAATGACAGTGATGGGCGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14447.60 Da
• Isoelectric Point: 8.5005

>AT75987 WP_086093620.1 NZ_CP021107:c3667934-3667533 [Bordetella genomosp. 6]
MKCPGCGAAALARDTRDMPYSYKGEATTIAAVTGDWCPACGESVLDGVESARVGEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT75987 NZ_CP021107:c3667934-3667533 [Bordetella genomosp. 6]
ATGAAGTGTCCCGGATGCGGGGCGGCCGCGCTGGCGCGCGATACCCGCGACATGCCTTACAGCTACAAGGGCGAGGCCAC
CACGATCGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAGCGTGCTCGATGGCGTCGAGTCGGCGCGGGTGG
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGATCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTCTTCGGTGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGCGCGGATT
GA