Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2403465..2403982 Replicon chromosome
Accession NZ_CP021105
Organism Staphylococcus aureus strain CC5

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag B4893_RS12500 Protein ID WP_000113265.1
Coordinates 2403465..2403731 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag B4893_RS12505 Protein ID WP_000584499.1
Coordinates 2403731..2403982 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4893_RS12470 2398893..2399429 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
B4893_RS12475 2399663..2400487 - 825 WP_000572038.1 formate/nitrite transporter family protein -
B4893_RS12480 2400704..2400886 - 183 WP_000230292.1 hypothetical protein -
B4893_RS12485 2400970..2401437 - 468 WP_000153347.1 SRPBCC domain-containing protein -
B4893_RS12490 2401623..2403170 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
B4893_RS12495 2403359..2403430 - 72 Protein_2299 hypothetical protein -
B4893_RS12500 2403465..2403731 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
B4893_RS12505 2403731..2403982 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B4893_RS12510 2404147..2404248 - 102 Protein_2302 hypothetical protein -
B4893_RS12515 2404255..2404854 - 600 WP_000162810.1 DsbA family protein -
B4893_RS12520 2404873..2405235 - 363 WP_000819843.1 DUF4467 domain-containing protein -
B4893_RS12525 2405490..2406740 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
B4893_RS12530 2406837..2407568 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
B4893_RS12535 2407565..2408284 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T75981 WP_000113265.1 NZ_CP021105:c2403731-2403465 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T75981 NZ_CP021105:c2403731-2403465 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT75981 WP_000584499.1 NZ_CP021105:c2403982-2403731 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT75981 NZ_CP021105:c2403982-2403731 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References