Detailed information of TA system TA075979

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2143904..2144120
• Replicon: chromosome
• Accession: NZ_CP021105
• Organism: Staphylococcus aureus strain CC5

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: B4893_RS11100
• Protein ID: WP_001802298.1
• Coordinates: 2144016..2144120 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2143904..2143959 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4893_RS11070	2139739..2140404	-	666	WP_001024095.1	SDR family oxidoreductase	-
B4893_RS11075	2140556..2140876	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
B4893_RS11080	2140878..2141855	+	978	WP_094659716.1	CDF family zinc efflux transporter CzrB	-
B4893_RS11085	2142121..2142633	+	513	Protein_2038	transcriptional regulator	-
B4893_RS11090	2142629..2142727	-	99	Protein_2039	SAM-dependent methyltransferase	-
B4893_RS11095	2142876..2143583	+	708	Protein_2040	transcriptional regulator	-
-	2143904..2143959	+	56	-	-	Antitoxin
B4893_RS11100	2144016..2144120	-	105	WP_001802298.1	hypothetical protein	Toxin
B4893_RS11110	2144800..2144958	+	159	WP_001792784.1	hypothetical protein	-
B4893_RS11120	2145616..2146473	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
B4893_RS11125	2146541..2147323	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T75979 WP_001802298.1 NZ_CP021105:c2144120-2144016 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T75979 NZ_CP021105:c2144120-2144016 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75979 NZ_CP021105:2143904-2143959 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin