Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4699041..4699563 Replicon chromosome
Accession NZ_CP021070
Organism Mesorhizobium sp. WSM1497

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A9K65_RS22975 Protein ID WP_063172049.1
Coordinates 4699378..4699563 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A9K65_RS22970 Protein ID WP_064995806.1
Coordinates 4699041..4699340 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9K65_RS22955 4695765..4696052 - 288 WP_013531907.1 succinate dehydrogenase assembly factor 2 -
A9K65_RS22960 4696145..4698253 + 2109 WP_064995807.1 ATP-dependent DNA helicase RecG -
A9K65_RS22965 4698205..4698960 - 756 WP_024503567.1 DUF502 domain-containing protein -
A9K65_RS22970 4699041..4699340 - 300 WP_064995806.1 HigA family addiction module antidote protein Antitoxin
A9K65_RS22975 4699378..4699563 - 186 WP_063172049.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9K65_RS22980 4699574..4701397 - 1824 WP_013531911.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
A9K65_RS22985 4701570..4702928 - 1359 WP_064995805.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
A9K65_RS22990 4703076..4703513 - 438 WP_013531913.1 hypothetical protein -
A9K65_RS22995 4703596..4704342 - 747 WP_063173667.1 cytochrome c biogenesis CcdA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-61)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6794.59 Da        Isoelectric Point: 6.7112

>T75949 WP_063172049.1 NZ_CP021070:c4699563-4699378 [Mesorhizobium sp. WSM1497]
ILRAIANAAQLNDLRSPPGNHLEALNGSRAGQHSIRINDQWRICFKWTAAGAEDVEIVDYH

Download         Length: 186 bp

>T75949 NZ_CP021070:c4699563-4699378 [Mesorhizobium sp. WSM1497]
ATCTTGCGCGCAATTGCCAATGCTGCCCAACTGAATGACCTTCGATCGCCGCCCGGAAATCATCTTGAAGCCCTGAACGG
GAGCCGAGCCGGACAGCATTCAATTCGCATCAACGACCAGTGGCGCATCTGCTTCAAATGGACCGCTGCTGGCGCTGAAG
ACGTGGAGATCGTCGATTACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11367.28 Da        Isoelectric Point: 5.9082

>AT75949 WP_064995806.1 NZ_CP021070:c4699340-4699041 [Mesorhizobium sp. WSM1497]
MLKFARPVHPGEFLREEYLVPLGMSVGALAKKLNLPRTRIERIAKEEIGLTPDTALRLARFFNTTPEFWMNFQPAYELET
EARKLAPELEKIEPLEVAA

Download         Length: 300 bp

>AT75949 NZ_CP021070:c4699340-4699041 [Mesorhizobium sp. WSM1497]
ATGCTCAAGTTCGCACGTCCAGTTCATCCTGGAGAATTCCTGCGTGAAGAATATCTCGTCCCGCTCGGCATGAGTGTAGG
CGCGCTGGCGAAAAAGCTCAACCTTCCGCGCACCCGTATCGAACGCATTGCCAAGGAAGAGATCGGCCTGACTCCCGATA
CCGCTCTTCGCCTCGCCAGATTTTTCAACACCACGCCCGAATTCTGGATGAATTTTCAACCGGCCTATGAGCTTGAAACC
GAAGCCAGAAAGCTGGCGCCGGAGCTCGAGAAGATTGAGCCGTTGGAAGTAGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References