Detailed information of TA system TA075931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 1157030..1157541
• Replicon: chromosome
• Accession: NZ_CP021059
• Organism: Macrococcus canis strain KM 45013

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MCCS_RS05850
• Protein ID: WP_086042490.1
• Coordinates: 1157281..1157541 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MCCS_RS05845
• Protein ID: WP_086042489.1
• Coordinates: 1157030..1157281 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCCS_RS05810	1152484..1153425	+	942	WP_086042482.1	LCP family protein	-
MCCS_RS05815	1153463..1153651	-	189	WP_086042483.1	4-oxalocrotonate tautomerase	-
MCCS_RS05820	1153700..1154704	-	1005	WP_086042484.1	cation diffusion facilitator family transporter	-
MCCS_RS05825	1154842..1155312	+	471	WP_086042485.1	GNAT family N-acetyltransferase	-
MCCS_RS05830	1155419..1155805	+	387	WP_086042486.1	sporulation protein	-
MCCS_RS05835	1155868..1156383	-	516	WP_086042487.1	DUF402 domain-containing protein	-
MCCS_RS05840	1156476..1156934	+	459	WP_086042488.1	NUDIX domain-containing protein	-
MCCS_RS05845	1157030..1157281	+	252	WP_086042489.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MCCS_RS05850	1157281..1157541	+	261	WP_086042490.1	Txe/YoeB family addiction module toxin	Toxin
MCCS_RS05855	1157542..1157991	-	450	WP_086042491.1	GNAT family N-acetyltransferase	-
MCCS_RS05860	1158209..1159099	+	891	WP_086042492.1	phosphotransferase	-
MCCS_RS05865	1159131..1159313	+	183	WP_086042493.1	hypothetical protein	-
MCCS_RS05870	1159319..1160080	+	762	WP_086042494.1	hypothetical protein	-
MCCS_RS05875	1160103..1160375	-	273	WP_086042495.1	Txe/YoeB family addiction module toxin	-
MCCS_RS05880	1160368..1160625	-	258	WP_086042496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MCCS_RS05885	1160914..1161138	+	225	WP_086042497.1	toxin-antitoxin system, antitoxin component	-
MCCS_RS05890	1161135..1161401	+	267	WP_086042498.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MCCS_RS05895	1161512..1161880	+	369	WP_086042499.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10315.08 Da
• Isoelectric Point: 10.4623

>T75931 WP_086042490.1 NZ_CP021059:1157281-1157541 [Macrococcus canis]
MYKIVMKSSVKKDLKKIKNTHLEPNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEFKIVTIYS
AYGHYK

Nucleotide

• Length: 261 bp

>T75931 NZ_CP021059:1157281-1157541 [Macrococcus canis]
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATTAAAAACACGCACTTAGAACCGAACTTTCT
AAAAATCATTAATCAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATCCCCCCAATAAAGGGAT
TTTATTCGAGAAGGATAAATGTACAACATCGTGTTGTTTATACTGTAAATGACGAATTTAAAATTGTAACAATTTATTCA
GCATATGGACATTATAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9590.65 Da
• Isoelectric Point: 4.0373

>AT75931 WP_086042489.1 NZ_CP021059:1157030-1157281 [Macrococcus canis]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Nucleotide

• Length: 252 bp

>AT75931 NZ_CP021059:1157030-1157281 [Macrococcus canis]
ATGAATACTTATACACCAACAAGTGCTAGAAAAGATTTTTTCAACATCATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCACCAACTAAAATTGGAGAAAAAGGTGCTGTTTTAGTCGGCGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA