75929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1156404..1156926 Replicon chromosome
Accession NZ_CP021058
Organism Macrococcus caseolyticus strain IMD0819

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CA207_RS05925 Protein ID WP_086038670.1
Coordinates 1156404..1156676 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CA207_RS05930 Protein ID WP_086038671.1
Coordinates 1156669..1156926 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA207_RS05895 1152436..1152822 + 387 WP_050742435.1 sporulation protein -
CA207_RS05900 1152923..1153372 - 450 WP_086038665.1 GNAT family N-acetyltransferase -
CA207_RS05905 1153455..1154195 + 741 WP_086038666.1 hypothetical protein -
CA207_RS05910 1154205..1155095 + 891 WP_086038667.1 phosphotransferase -
CA207_RS05915 1155127..1155612 + 486 WP_086038668.1 NUDIX domain-containing protein -
CA207_RS05920 1155627..1156376 + 750 WP_086038669.1 hypothetical protein -
CA207_RS05925 1156404..1156676 - 273 WP_086038670.1 Txe/YoeB family addiction module toxin Toxin
CA207_RS05930 1156669..1156926 - 258 WP_086038671.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CA207_RS05935 1157057..1158229 - 1173 WP_086038672.1 MFS transporter -
CA207_RS05940 1158414..1159028 - 615 WP_086038673.1 DJ-1/PfpI family protein -
CA207_RS05945 1159103..1160206 - 1104 WP_076688030.1 IS30 family transposase -
CA207_RS05950 1161024..1161695 + 672 WP_086038674.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10684.42 Da        Isoelectric Point: 9.7524

>T75929 WP_086038670.1 NZ_CP021058:c1156676-1156404 [Macrococcus caseolyticus]
MSKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T75929 NZ_CP021058:c1156676-1156404 [Macrococcus caseolyticus]
ATGTCTAAGAAAAAGATACTTTTTTATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCGAATGAAGGCATAGGTAAGCCGGAAAAATTATTAG
GAAACTATACCGGTTGCTATAGCAGAAGGATCACTCATGAACATAGGCTCGTATATAAGATAGAAGATGATTCAATTTGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9738.84 Da        Isoelectric Point: 4.0936

>AT75929 WP_086038671.1 NZ_CP021058:c1156926-1156669 [Macrococcus caseolyticus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLEVE
IDLDV

Download         Length: 258 bp

>AT75929 NZ_CP021058:c1156926-1156669 [Macrococcus caseolyticus]
ATGAAAGTTACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGATTGTGAACCTTA
CACAATAACAACAAATACACATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTATTTAC
AGAGTACACCAGCAAATGCCGAAAGATTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTAGAAGTTGAG
ATAGATTTAGATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References