Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4994040..4994461 Replicon chromosome
Accession NZ_CP020971
Organism Xanthomonas phaseoli pv. phaseoli strain CFBP6546R

Toxin (Protein)


Gene name higB Uniprot ID A0A3Q9Q4S9
Locus tag XppCFBP6546P_RS21575 Protein ID WP_017156024.1
Coordinates 4994348..4994461 (-) Length 38 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XppCFBP6546P_RS21570 Protein ID WP_017156025.1
Coordinates 4994040..4994330 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XppCFBP6546P_RS21545 (XppCFBP6546P_12125) 4989375..4989707 + 333 WP_003482333.1 hypothetical protein -
XppCFBP6546P_RS21555 (XppCFBP6546P_12115) 4990022..4991947 + 1926 WP_039574551.1 M61 family metallopeptidase -
XppCFBP6546P_RS21560 (XppCFBP6546P_12110) 4992015..4992194 + 180 WP_039574549.1 hypothetical protein -
XppCFBP6546P_RS21565 (XppCFBP6546P_12105) 4992297..4993685 - 1389 WP_039574546.1 type III secretion system effector XopQ -
XppCFBP6546P_RS21570 (XppCFBP6546P_12095) 4994040..4994330 - 291 WP_017156025.1 HigA family addiction module antitoxin Antitoxin
XppCFBP6546P_RS21575 (XppCFBP6546P_24130) 4994348..4994461 - 114 WP_017156024.1 hypothetical protein Toxin
XppCFBP6546P_RS21580 (XppCFBP6546P_12085) 4994726..4997233 - 2508 WP_046834789.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4945616..5018369 72753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 4677.41 Da        Isoelectric Point: 9.1273

>T75843 WP_017156024.1 NZ_CP020971:c4994461-4994348 [Xanthomonas phaseoli pv. phaseoli]
MKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Download         Length: 114 bp

>T75843 NZ_CP020971:c4994461-4994348 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10387.09 Da        Isoelectric Point: 9.0188

>AT75843 WP_017156025.1 NZ_CP020971:c4994330-4994040 [Xanthomonas phaseoli pv. phaseoli]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT75843 NZ_CP020971:c4994330-4994040 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9Q4S9

Antitoxin

Source ID Structure

References