Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2612289..2612806 Replicon chromosome
Accession NZ_CP020960
Organism Staphylococcus aureus strain JK3137

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag B9T46_RS13990 Protein ID WP_000113262.1
Coordinates 2612289..2612555 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag B9T46_RS13995 Protein ID WP_000584502.1
Coordinates 2612555..2612806 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T46_RS13960 2607715..2608251 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
B9T46_RS13965 2608484..2609308 - 825 WP_000572040.1 formate/nitrite transporter family protein -
B9T46_RS13970 2609525..2609707 - 183 WP_000230294.1 hypothetical protein -
B9T46_RS13975 2609791..2610258 - 468 WP_000153344.1 SRPBCC domain-containing protein -
B9T46_RS13980 2610444..2611994 - 1551 WP_050957248.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
B9T46_RS13985 2612183..2612254 - 72 Protein_2591 hypothetical protein -
B9T46_RS13990 2612289..2612555 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
B9T46_RS13995 2612555..2612806 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B9T46_RS14000 2612971..2613072 - 102 WP_001791744.1 hypothetical protein -
B9T46_RS14005 2613079..2613678 - 600 WP_000162813.1 DsbA family protein -
B9T46_RS14010 2613697..2614056 - 360 WP_000819847.1 DUF4467 domain-containing protein -
B9T46_RS14015 2614311..2615561 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
B9T46_RS14020 2615658..2616389 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
B9T46_RS14025 2616386..2617105 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T75831 WP_000113262.1 NZ_CP020960:c2612555-2612289 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T75831 NZ_CP020960:c2612555-2612289 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT75831 WP_000584502.1 NZ_CP020960:c2612806-2612555 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT75831 NZ_CP020960:c2612806-2612555 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References