Detailed information of TA system TA075830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2347584..2347801
• Replicon: chromosome
• Accession: NZ_CP020960
• Organism: Staphylococcus aureus strain JK3137

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: B9T46_RS12565
• Protein ID: WP_001802298.1
• Coordinates: 2347697..2347801 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2347584..2347639 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T46_RS12545	2343721..2344386	-	666	WP_001024094.1	SDR family oxidoreductase	-
B9T46_RS12550	2344538..2344858	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
B9T46_RS12555	2344860..2345840	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
B9T46_RS12560	2346106..2347197	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2347584..2347639	+	56	-	-	Antitoxin
B9T46_RS12565	2347697..2347801	-	105	WP_001802298.1	hypothetical protein	Toxin
B9T46_RS15825	2347962..2348445	-	484	Protein_2325	recombinase family protein	-
B9T46_RS12575	2348488..2349624	-	1137	WP_000115564.1	SAP domain-containing protein	-
B9T46_RS12580	2349913..2350005	+	93	WP_001790138.1	hypothetical protein	-
B9T46_RS12585	2350710..2351567	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
B9T46_RS12590	2351635..2352417	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T75830 WP_001802298.1 NZ_CP020960:c2347801-2347697 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T75830 NZ_CP020960:c2347801-2347697 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75830 NZ_CP020960:2347584-2347639 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin