Detailed information of TA system TA075822

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2074758..2074940
• Replicon: chromosome
• Accession: NZ_CP020960
• Organism: Staphylococcus aureus strain JK3137

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: B9T46_RS10835
• Protein ID: WP_001801861.1
• Coordinates: 2074758..2074853 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2074881..2074940 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T46_RS10785	2070419..2071044	+	626	Protein_2033	hypothetical protein	-
B9T46_RS10790	2071085..2071429	+	345	WP_000627551.1	DUF3969 family protein	-
B9T46_RS10795	2071527..2072078	+	552	WP_000414205.1	hypothetical protein	-
B9T46_RS10800	2072296..2072937	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
B9T46_RS10805	2073051..2073236	-	186	WP_000809857.1	hypothetical protein	-
B9T46_RS10810	2073238..2073414	-	177	WP_000375476.1	hypothetical protein	-
B9T46_RS10815	2073425..2073808	-	384	WP_000070811.1	hypothetical protein	-
B9T46_RS10825	2074412..2074555	-	144	WP_001549059.1	transposase	-
B9T46_RS10835	2074758..2074853	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2074881..2074940	-	60	-	-	Antitoxin
B9T46_RS10840	2074976..2075077	+	102	WP_001791893.1	hypothetical protein	-
B9T46_RS10845	2075055..2075231	-	177	Protein_2043	transposase	-
B9T46_RS10850	2075425..2075802	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T75822 WP_001801861.1 NZ_CP020960:2074758-2074853 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T75822 NZ_CP020960:2074758-2074853 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT75822 NZ_CP020960:c2074940-2074881 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin