Detailed information of TA system TA075818

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 951779..952117
• Replicon: chromosome
• Accession: NZ_CP020960
• Organism: Staphylococcus aureus strain JK3137

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: B9T46_RS04940
• Protein ID: WP_011447039.1
• Coordinates: 951779..951955 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	951943..952117 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T46_RS04920	947014..950799	+	3786	WP_000582165.1	hypothetical protein	-
B9T46_RS04925	950789..950941	+	153	WP_001153681.1	hypothetical protein	-
B9T46_RS04930	950988..951275	+	288	WP_001040261.1	hypothetical protein	-
B9T46_RS04935	951333..951629	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
B9T46_RS04940	951779..951955	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	951943..952117	-	175	-	-	Antitoxin
B9T46_RS04950	952167..952421	+	255	WP_000611512.1	phage holin	-
B9T46_RS04955	952433..953188	+	756	WP_000861038.1	CHAP domain-containing protein	-
B9T46_RS04960	953379..953870	+	492	WP_000919350.1	staphylokinase	-
B9T46_RS04970	954520..954855	+	336	Protein_923	SH3 domain-containing protein	-
B9T46_RS04975	954950..955399	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
B9T46_RS04980	956083..956433	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
B9T46_RS04985	956486..956746	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / sak / chp / scn	876882..956433	79551

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T75818 WP_011447039.1 NZ_CP020960:951779-951955 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T75818 NZ_CP020960:951779-951955 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT75818 NZ_CP020960:c952117-951943 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin