Detailed information of TA system TA075801

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 136241..136540
• Replicon: chromosome
• Accession: NZ_CP020959
• Organism: Staphylococcus aureus strain H489

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: B9T45_RS00675
• Protein ID: WP_011447039.1
• Coordinates: 136364..136540 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	136241..136296 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T45_RS00615	131801..131980	+	180	WP_000669791.1	hypothetical protein	-
B9T45_RS00625	132290..132550	+	261	WP_001791826.1	hypothetical protein	-
B9T45_RS00630	132603..132953	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
B9T45_RS00635	133463..133798	-	336	Protein_115	SH3 domain-containing protein	-
B9T45_RS00655	134449..134940	-	492	WP_031865878.1	staphylokinase	-
B9T45_RS00660	135131..135886	-	756	WP_000861038.1	CHAP domain-containing protein	-
B9T45_RS00665	135898..136152	-	255	WP_000611512.1	phage holin	-
B9T45_RS00670	136204..136311	+	108	WP_001791821.1	hypothetical protein	-
-	136233..136372	+	140	NuclAT_0	-	-
-	136233..136372	+	140	NuclAT_0	-	-
-	136233..136372	+	140	NuclAT_0	-	-
-	136233..136372	+	140	NuclAT_0	-	-
-	136241..136296	+	56	-	-	Antitoxin
B9T45_RS00675	136364..136540	-	177	WP_011447039.1	putative holin-like toxin	Toxin
B9T45_RS00680	136649..137422	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
B9T45_RS00685	137795..138169	-	375	WP_000340977.1	hypothetical protein	-
B9T45_RS00690	138225..138512	-	288	WP_001262621.1	hypothetical protein	-
B9T45_RS00695	138558..138710	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	cap8D / cap8E / cap8F / cap8G / cap8L / scn / sak / sea / cap8L / cap8M	122571..175522	52951

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T75801 WP_011447039.1 NZ_CP020959:c136540-136364 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T75801 NZ_CP020959:c136540-136364 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75801 NZ_CP020959:136241-136296 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin