Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2478265..2478449 Replicon chromosome
Accession NZ_CP020957
Organism Staphylococcus aureus strain C3948

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag B9T42_RS13020 Protein ID WP_000482650.1
Coordinates 2478342..2478449 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2478265..2478325 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T42_RS12995 2473795..2473962 - 168 WP_001790576.1 hypothetical protein -
B9T42_RS13005 2474193..2475926 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
B9T42_RS13010 2475951..2477714 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2478265..2478325 + 61 - - Antitoxin
B9T42_RS13020 2478342..2478449 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
B9T42_RS13025 2478583..2478969 - 387 WP_000779358.1 flippase GtxA -
B9T42_RS13030 2479237..2480379 + 1143 WP_001176863.1 glycerate kinase -
B9T42_RS13035 2480439..2481098 + 660 WP_000831298.1 membrane protein -
B9T42_RS13040 2481280..2482491 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
B9T42_RS13045 2482614..2483087 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T75798 WP_000482650.1 NZ_CP020957:c2478449-2478342 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T75798 NZ_CP020957:c2478449-2478342 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT75798 NZ_CP020957:2478265-2478325 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References