Detailed information of TA system TA075789

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2013278..2013577
• Replicon: chromosome
• Accession: NZ_CP020957
• Organism: Staphylococcus aureus strain C3948

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: B9T42_RS10420
• Protein ID: WP_011447039.1
• Coordinates: 2013401..2013577 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2013278..2013333 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T42_RS10375	2008613..2008873	+	261	WP_001791826.1	hypothetical protein	-
B9T42_RS10380	2008926..2009276	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
B9T42_RS10385	2009957..2010406	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
B9T42_RS10390	2010501..2010836	-	336	Protein_1912	SH3 domain-containing protein	-
B9T42_RS10400	2011486..2011977	-	492	WP_000919350.1	staphylokinase	-
B9T42_RS10405	2012168..2012923	-	756	WP_000861038.1	CHAP domain-containing protein	-
B9T42_RS10410	2012935..2013189	-	255	WP_000611512.1	phage holin	-
B9T42_RS10415	2013241..2013348	+	108	WP_001791821.1	hypothetical protein	-
-	2013270..2013409	+	140	NuclAT_0	-	-
-	2013270..2013409	+	140	NuclAT_0	-	-
-	2013270..2013409	+	140	NuclAT_0	-	-
-	2013270..2013409	+	140	NuclAT_0	-	-
-	2013278..2013333	+	56	-	-	Antitoxin
B9T42_RS10420	2013401..2013577	-	177	WP_011447039.1	putative holin-like toxin	Toxin
B9T42_RS10425	2013727..2014023	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
B9T42_RS10430	2014081..2014368	-	288	WP_001040261.1	hypothetical protein	-
B9T42_RS10435	2014415..2014567	-	153	WP_001153681.1	hypothetical protein	-
B9T42_RS10440	2014557..2018342	-	3786	WP_129940477.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	2005109..2064830	59721

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T75789 WP_011447039.1 NZ_CP020957:c2013577-2013401 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T75789 NZ_CP020957:c2013577-2013401 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75789 NZ_CP020957:2013278-2013333 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin