75784

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2548727..2549250 Replicon chromosome
Accession NZ_CP020956
Organism Staphylococcus aureus strain C8879

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag B9T41_RS13440 Protein ID WP_000074048.1
Coordinates 2548727..2548993 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag B9T41_RS13445 Protein ID WP_000587616.1
Coordinates 2548993..2549250 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T41_RS13420 2544034..2545221 - 1188 WP_000026194.1 MFS transporter -
B9T41_RS13425 2545617..2546393 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
B9T41_RS13430 2546386..2547048 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
B9T41_RS13435 2547296..2548372 - 1077 WP_001076671.1 M42 family metallopeptidase -
B9T41_RS13440 2548727..2548993 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
B9T41_RS13445 2548993..2549250 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B9T41_RS13455 2549609..2550064 + 456 WP_000732082.1 DUF1307 domain-containing protein -
B9T41_RS13460 2550232..2551809 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
B9T41_RS13465 2552004..2552753 + 750 WP_000072444.1 hypothetical protein -
B9T41_RS13470 2552977..2554170 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T75784 WP_000074048.1 NZ_CP020956:c2548993-2548727 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T75784 NZ_CP020956:c2548993-2548727 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT75784 WP_000587616.1 NZ_CP020956:c2549250-2548993 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT75784 NZ_CP020956:c2549250-2548993 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References