Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2227174..2227391 Replicon chromosome
Accession NZ_CP020956
Organism Staphylococcus aureus strain C8879

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag B9T41_RS11695 Protein ID WP_001802298.1
Coordinates 2227287..2227391 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2227174..2227229 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T41_RS11675 2223311..2223976 - 666 WP_001024094.1 SDR family oxidoreductase -
B9T41_RS11680 2224128..2224448 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
B9T41_RS11685 2224450..2225430 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
B9T41_RS11690 2225696..2226787 + 1092 WP_000495671.1 lytic regulatory protein -
- 2227174..2227229 + 56 - - Antitoxin
B9T41_RS11695 2227287..2227391 - 105 WP_001802298.1 hypothetical protein Toxin
B9T41_RS14890 2227552..2228035 - 484 Protein_2152 recombinase family protein -
B9T41_RS11705 2228078..2229214 - 1137 WP_048519528.1 SAP domain-containing protein -
B9T41_RS11710 2229503..2229595 + 93 WP_001790138.1 hypothetical protein -
B9T41_RS11715 2230300..2231157 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
B9T41_RS11720 2231225..2232007 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T75780 WP_001802298.1 NZ_CP020956:c2227391-2227287 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T75780 NZ_CP020956:c2227391-2227287 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT75780 NZ_CP020956:2227174-2227229 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References