75776

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2076402..2076816 Replicon chromosome
Accession NZ_CP020956
Organism Staphylococcus aureus strain C8879

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B9T41_RS10830 Protein ID WP_001065046.1
Coordinates 2076565..2076816 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B9T41_RS14885 Protein ID WP_000028424.1
Coordinates 2076402..2076575 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9T41_RS10770 2071967..2072311 - 345 WP_000817289.1 HNH endonuclease -
B9T41_RS10775 2072327..2072779 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
B9T41_RS10780 2072894..2073364 - 471 WP_000282758.1 hypothetical protein -
B9T41_RS10790 2073387..2073587 - 201 WP_000265041.1 DUF1514 family protein -
B9T41_RS10795 2073587..2074236 - 650 Protein_1982 hypothetical protein -
B9T41_RS10800 2074395..2074544 - 150 WP_000595305.1 transcriptional activator RinB -
B9T41_RS10805 2074541..2074927 - 387 WP_000592201.1 hypothetical protein -
B9T41_RS10810 2074924..2075130 - 207 WP_000195803.1 DUF1381 domain-containing protein -
B9T41_RS10815 2075127..2075372 - 246 WP_050960402.1 hypothetical protein -
B9T41_RS10820 2075409..2075942 - 534 WP_001061838.1 dUTP diphosphatase -
B9T41_RS14880 2075957..2076118 - 162 WP_000889682.1 hypothetical protein -
B9T41_RS10825 2076119..2076376 - 258 WP_031866878.1 hypothetical protein -
B9T41_RS14885 2076402..2076575 - 174 WP_000028424.1 hypothetical protein Antitoxin
B9T41_RS10830 2076565..2076816 - 252 WP_001065046.1 DUF1024 family protein Toxin
B9T41_RS10835 2076831..2077073 - 243 WP_000131381.1 phi PVL orf 51-like protein -
B9T41_RS10840 2077077..2077445 - 369 WP_000101270.1 hypothetical protein -
B9T41_RS10845 2077458..2077913 - 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
B9T41_RS10850 2077922..2078140 - 219 WP_000338527.1 hypothetical protein -
B9T41_RS10855 2078147..2079040 - 894 WP_000148327.1 DnaD domain-containing protein -
B9T41_RS10860 2079070..2079540 - 471 WP_000934762.1 single-stranded DNA-binding protein -
B9T41_RS10865 2079541..2080158 - 618 WP_072353921.1 MBL fold metallo-hydrolase -
B9T41_RS10870 2080239..2081159 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 2048054..2104098 56044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T75776 WP_001065046.1 NZ_CP020956:c2076816-2076565 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T75776 NZ_CP020956:c2076816-2076565 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT75776 WP_000028424.1 NZ_CP020956:c2076575-2076402 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT75776 NZ_CP020956:c2076575-2076402 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References