Detailed information of TA system TA075772

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2051693..2051992
• Replicon: chromosome
• Accession: NZ_CP020956
• Organism: Staphylococcus aureus strain C8879

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: B9T41_RS10665
• Protein ID: WP_072353918.1
• Coordinates: 2051816..2051992 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2051693..2051748 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9T41_RS10605	2047251..2047430	+	180	WP_000669791.1	hypothetical protein	-
B9T41_RS10615	2047741..2048001	+	261	WP_001791826.1	hypothetical protein	-
B9T41_RS10620	2048054..2048404	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
B9T41_RS10625	2048915..2049250	-	336	Protein_1952	SH3 domain-containing protein	-
B9T41_RS10645	2049901..2050392	-	492	WP_000920038.1	staphylokinase	-
B9T41_RS10650	2050583..2051338	-	756	WP_000861038.1	CHAP domain-containing protein	-
B9T41_RS10655	2051350..2051604	-	255	WP_000611512.1	phage holin	-
B9T41_RS10660	2051656..2051763	+	108	WP_001791821.1	hypothetical protein	-
-	2051685..2051824	+	140	NuclAT_0	-	-
-	2051685..2051824	+	140	NuclAT_0	-	-
-	2051685..2051824	+	140	NuclAT_0	-	-
-	2051685..2051824	+	140	NuclAT_0	-	-
-	2051693..2051748	+	56	-	-	Antitoxin
B9T41_RS10665	2051816..2051992	-	177	WP_072353918.1	putative holin-like toxin	Toxin
B9T41_RS10670	2052135..2052508	-	374	Protein_1958	hypothetical protein	-
B9T41_RS10675	2052564..2052851	-	288	WP_001262620.1	hypothetical protein	-
B9T41_RS10680	2052897..2053049	-	153	WP_001000058.1	hypothetical protein	-
B9T41_RS10685	2053042..2056824	-	3783	WP_048519605.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2048054..2104098	56044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T75772 WP_072353918.1 NZ_CP020956:c2051992-2051816 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T75772 NZ_CP020956:c2051992-2051816 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75772 NZ_CP020956:2051693-2051748 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin