Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1943872..1944476 Replicon chromosome
Accession NZ_CP020894
Organism Legionella longbeachae strain F1157CHC

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B0B39_RS08530 Protein ID WP_085662369.1
Coordinates 1944165..1944476 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0W0SK75
Locus tag B0B39_RS08525 Protein ID WP_058441751.1
Coordinates 1943872..1944162 (-) Length 97 a.a.

Genomic Context

B0B39_RS08535B0B39_RS08540B0B39_RS08500B0B39_RS08505B0B39_RS08510B0B39_RS08515B0B39_RS18750B0B39_RS08520B0B39_RS08525B0B39_RS08530B0B39_RS08545B0B39_RS08550B0B39_RS08555
Location: 1944717..1945136 (420 bp)
Type: Others
Protein ID: WP_085662371.1
Location: 1945292..1946101 (810 bp)
Type: Others
Protein ID: WP_085662373.1
Location: 1939309..1940619 (1311 bp)
Type: Others
Protein ID: WP_085662366.1
Location: 1940916..1941788 (873 bp)
Type: Others
Protein ID: WP_085662367.1
Location: 1942087..1942407 (321 bp)
Type: Others
Protein ID: WP_003631575.1
Location: 1942397..1942696 (300 bp)
Type: Others
Protein ID: WP_003631574.1
Location: 1942749..1942910 (162 bp)
Type: Others
Protein ID: WP_003631573.1
Location: 1942962..1943393 (432 bp)
Type: Others
Protein ID: WP_003631571.1
Location: 1943872..1944162 (291 bp)
Type: Antitoxin
Protein ID: WP_058441751.1
Location: 1944165..1944476 (312 bp)
Type: Toxin
Protein ID: WP_085662369.1
Location: 1946497..1946931 (435 bp)
Type: Others
Protein ID: WP_085662375.1
Location: 1947118..1947816 (699 bp)
Type: Others
Protein ID: WP_085662376.1
Location: 1947866..1948414 (549 bp)
Type: Others
Protein ID: WP_085662378.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B0B39_RS085001939309..1940619-1311WP_085662366.1hypothetical protein-
B0B39_RS085051940916..1941788-873WP_085662367.1helix-turn-helix transcriptional regulator-
B0B39_RS085101942087..1942407-321WP_003631575.1helix-turn-helix domain-containing protein-
B0B39_RS085151942397..1942696-300WP_003631574.1hypothetical protein-
B0B39_RS187501942749..1942910-162WP_003631573.1hypothetical protein-
B0B39_RS085201942962..1943393-432WP_003631571.1hypothetical protein-
B0B39_RS085251943872..1944162-291WP_058441751.1helix-turn-helix domain-containing proteinAntitoxin
B0B39_RS085301944165..1944476-312WP_085662369.1hypothetical proteinToxin
B0B39_RS085351944717..1945136+420WP_085662371.1hypothetical protein-
B0B39_RS085401945292..1946101+810WP_085662373.1hypothetical protein-
B0B39_RS085451946497..1946931-435WP_085662375.1type II toxin-antitoxin system PemK/MazF family toxin-
B0B39_RS085501947118..1947816-699WP_085662376.1hypothetical protein-
B0B39_RS085551947866..1948414-549WP_085662378.1recombinase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12001.74 Da        Isoelectric Point: 6.3489

>T75643 WP_085662369.1 NZ_CP020894:c1944476-1944165 [Legionella longbeachae]
MIFIETPIFTEDVKELLSDEEYADFQDYLADNPLAGDVIQQTGGLRKVRWSSQGKGKRGGVRIIYYYVTPASQIRLLLIY
KKGIQDDLTTDQKKMLRQLNERW

Download         Length: 312 bp

>T75643 NZ_CP020894:c1944476-1944165 [Legionella longbeachae]
ATGATTTTTATTGAGACTCCAATTTTTACGGAAGATGTGAAAGAATTATTATCCGATGAGGAGTATGCTGATTTTCAAGA
TTATCTTGCTGATAATCCTTTAGCTGGAGACGTAATTCAGCAAACCGGTGGACTACGAAAGGTTCGATGGTCCTCTCAAG
GCAAAGGAAAACGAGGCGGTGTTAGAATTATTTATTATTATGTAACTCCTGCTTCACAAATAAGACTCTTACTTATTTAT
AAAAAAGGCATTCAAGATGATCTGACTACAGATCAAAAGAAAATGTTACGGCAATTAAATGAACGGTGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11028.73 Da        Isoelectric Point: 8.0670

>AT75643 WP_058441751.1 NZ_CP020894:c1944162-1943872 [Legionella longbeachae]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVNIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAS

Download         Length: 291 bp

>AT75643 NZ_CP020894:c1944162-1943872 [Legionella longbeachae]
ATGGATAAAAAATTATTTGAACGATTATACGAAAGTATGACTCAGATGAACGAAATTATTGATGGTGAGCGCGTTCCTTC
ACGCGAGTTCGTAGTAGATGCTGTTCATGTAAAAGAAATTAGAAAAAAAACAGGACTAACCCAAGAAAAATTTTGTCATT
TAATTGATGTAAATATTGGAACGTTAAGAAATTGGGAACAGGGGAGAAGAGAGCCAACAGGTCCCGCAAAAGCCCTTCTT
CGTGCAATAAATAAAGATCCTGAGCATGTATTAGCAGCATTAGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0W0SK75

References