Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 784764..785457 Replicon chromosome
Accession NZ_CP020835
Organism Escherichia coli strain CFSAN051542

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag BCD20_RS04120 Protein ID WP_000415584.1
Coordinates 784764..785060 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag BCD20_RS04125 Protein ID WP_000650107.1
Coordinates 785062..785457 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCD20_RS04085 779853..780221 + 369 Protein_736 Hcp family type VI secretion system effector -
BCD20_RS04090 780224..780934 + 711 WP_000834029.1 hypothetical protein -
BCD20_RS04095 780941..781273 + 333 WP_000914691.1 DUF2645 family protein -
BCD20_RS04100 781319..782668 - 1350 WP_000673354.1 two-component system sensor histidine kinase QseC -
BCD20_RS04105 782665..782790 - 126 Protein_740 winged helix-turn-helix domain-containing protein -
BCD20_RS04110 782846..784059 + 1214 WP_139371347.1 IS3 family transposase -
BCD20_RS04115 784134..784559 + 426 WP_044864279.1 GyrI-like domain-containing protein -
BCD20_RS04120 784764..785060 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
BCD20_RS04125 785062..785457 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
BCD20_RS04130 785590..787197 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
BCD20_RS04135 787335..789593 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T75466 WP_000415584.1 NZ_CP020835:784764-785060 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T75466 NZ_CP020835:784764-785060 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT75466 WP_000650107.1 NZ_CP020835:785062-785457 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT75466 NZ_CP020835:785062-785457 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References