Detailed information of TA system TA075440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1451500..1452155
• Replicon: chromosome
• Accession: NZ_CP020818
• Organism: Bordetella bronchiseptica strain F709

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: B9G73_RS06910
• Protein ID: WP_050461266.1
• Coordinates: 1451500..1451751 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: B9G73_RS06915
• Protein ID: WP_003819831.1
• Coordinates: 1451754..1452155 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9G73_RS06885	1446660..1447790	-	1131	WP_004568222.1	helix-turn-helix transcriptional regulator	-
B9G73_RS06890	1448025..1448567	+	543	WP_033839915.1	molybdenum cofactor biosysynthesis protein	-
B9G73_RS06895	1448743..1449807	+	1065	WP_003819826.1	fructose-bisphosphate aldolase class II	-
B9G73_RS06900	1449892..1450338	-	447	WP_003819827.1	GFA family protein	-
B9G73_RS06905	1450564..1451445	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
B9G73_RS06910	1451500..1451751	+	252	WP_050461266.1	type II toxin-antitoxin system MqsR family toxin	Toxin
B9G73_RS06915	1451754..1452155	+	402	WP_003819831.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B9G73_RS06920	1452175..1452411	+	237	WP_003819834.1	hypothetical protein	-
B9G73_RS06925	1452419..1452898	+	480	WP_003819836.1	disulfide bond formation protein B	-
B9G73_RS06930	1453049..1453564	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B9G73_RS06935	1453567..1454757	+	1191	WP_003819837.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B9G73_RS06940	1454777..1455814	+	1038	WP_003819838.1	threonylcarbamoyl-AMP synthase	-
B9G73_RS06945	1455951..1456973	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8926.43 Da
• Isoelectric Point: 9.7242

>T75440 WP_050461266.1 NZ_CP020818:1451500-1451751 [Bordetella bronchiseptica]
IGGAATKKPGQKRRAGAAALGLDFSAMVETVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPVVSF
KEL

Nucleotide

• Length: 252 bp

>T75440 NZ_CP020818:1451500-1451751 [Bordetella bronchiseptica]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAACCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGGATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGGTCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14559.72 Da
• Isoelectric Point: 8.5005

>AT75440 WP_003819831.1 NZ_CP020818:1451754-1452155 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCQACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT75440 NZ_CP020818:1451754-1452155 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTACAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCAGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA